Difference between revisions of "Soft tissue lesions"

Jump to navigation Jump to search

Soft tissue lesions (view source)

Revision as of 12:50, 3 November 2015

2,472 bytes removed ,  12:50, 3 November 2015
→‎Morphohistologic patterns
 
(2 intermediate revisions by the same user not shown)
Line 44: Line 44:


==Morphohistologic patterns==
==Morphohistologic patterns==
{{Main|Basics#Morphologic_patterns}}
{{Main|Morphologic patterns}}
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Name
! Name
Line 61: Line 61:
| [[Image:Malignant_peripheral_nerve_sheath_tumour_-_intermed_mag.jpg |thumb|center|150px |Herring bone. (WC)]]  
| [[Image:Malignant_peripheral_nerve_sheath_tumour_-_intermed_mag.jpg |thumb|center|150px |Herring bone. (WC)]]  
|-
|-
| Fasicular
| Fascicular
| the long axis of the (spindle) cells are perpendicular to one another in adjacent bundles of cells
| the long axis of the (spindle) cells are perpendicular to one another in adjacent bundles of cells
| [[leiomyoma]], [[leiomyosarcoma]]
| [[leiomyoma]], [[leiomyosarcoma]]
| [[Image:Cutaneous_leiomyosarcoma_-_high_mag.jpg |thumb|center|150px| Fasicular pattern. (WC)]]
| [[Image:Cutaneous_leiomyosarcoma_-_high_mag.jpg |thumb|center|150px| Fascicular pattern. (WC)]]
|-
|-
| Biphasic
| Biphasic
Line 282: Line 282:
==Extrarenal malignant rhabdoid tumour==
==Extrarenal malignant rhabdoid tumour==
*Essentially identical to ''[[renal malignant rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref>
*Essentially identical to ''[[renal malignant rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref>
===General===
{{Main|Extrarenal malignant rhabdoid tumour}}
*Usually children < 2 years old.
*Very poor prognosis ~ mean survival in one series 9 months.<ref name=pmid25085603>{{Cite journal  | last1 = Uwineza | first1 = A. | last2 = Gill | first2 = H. | last3 = Buckley | first3 = P. | last4 = Owens | first4 = C. | last5 = Capra | first5 = M. | last6 = O'Sullivan | first6 = C. | last7 = McDermott | first7 = M. | last8 = Brett | first8 = F. | last9 = Farrell | first9 = M. | title = Rhabdoid tumor: the Irish experience 1986-2013. | journal = Cancer Genet | volume = 207 | issue = 9 | pages = 398-402 | month = Sep | year = 2014 | doi = 10.1016/j.cancergen.2014.05.015 | PMID = 25085603 }}</ref>
*In the CNS it is known as ''[[atypical teratoid-rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref>
 
===Microscopic===
Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref>
*Variable architecture.
*Round cells.
*Eccentric vesicular nucleus.
*Prominent [[nucleolus]] -- '''key feature'''.
 
DDx:
*[[Desmoplastic small round cell tumour]].<ref name=pmid25133149>{{Cite journal  | last1 = Liang | first1 = L. | last2 = Tatevian | first2 = N. | last3 = Bhattacharjee | first3 = M. | last4 = Tsao | first4 = K. | last5 = Hicks | first5 = J. | title = Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation. | journal = World J Clin Cases | volume = 2 | issue = 8 | pages = 367-72 | month = Aug | year = 2014 | doi = 10.12998/wjcc.v2.i8.367 | PMID = 25133149 }}</ref>
*Rhabdoid [[melanoma]].<ref name=pmid24551314>{{Cite journal  | last1 = Ishida | first1 = M. | last2 = Iwai | first2 = M. | last3 = Yoshida | first3 = K. | last4 = Kagotani | first4 = A. | last5 = Okabe | first5 = H. | title = Rhabdoid melanoma: a case report with review of the literature. | journal = Int J Clin Exp Pathol | volume = 7 | issue = 2 | pages = 840-3 | month =  | year = 2014 | doi =  | PMID = 24551314 }}</ref>
 
===IHC===
*INI1 ([[SMARCB1]]) -ve.
**[[AKA]] BAF47.
 
Others:<ref name=pmid25623976>{{Cite journal  | last1 = Wang | first1 = H. | last2 = Ma | first2 = Y. | last3 = Li | first3 = J. | last4 = Zhang | first4 = D. | last5 = Wu | first5 = B. | last6 = Fang | first6 = C. | last7 = Chen | first7 = L. | title = [Extrarenal malignant rhabdoid tumor of childhood: a clinicopathologic analysis of 8 cases]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 43 | issue = 12 | pages = 805-8 | month = Dec | year = 2014 | doi =  | PMID = 25623976 }}</ref>
*Vimentin +ve.
*EMA +ve.
*AE1/AE3 +ve.
*CAM5.2 +ve.


==Ewing sarcoma/PNET==
==Ewing sarcoma/PNET==
Michael
48,436

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/37323...41045"

Navigation menu