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Difference between revisions of "Soft tissue lesions"
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→Alveolar soft part sarcoma: expand +IHC, +EM
(→Alveolar soft part sarcoma: +stains) |
(→Alveolar soft part sarcoma: expand +IHC, +EM) |
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| Line 482: | Line 482: | ||
*Adolescents/young adults. | *Adolescents/young adults. | ||
*Children -- classically location: base of [[tongue]] and orbit. | *Children -- classically location: base of [[tongue]] and orbit. | ||
*Typical indolent initially - ultimately a poor prognosis.<ref name=pmid17071801>{{Cite journal | last1 = Folpe | first1 = AL. | last2 = Deyrup | first2 = AT. | title = Alveolar soft-part sarcoma: a review and update. | journal = J Clin Pathol | volume = 59 | issue = 11 | pages = 1127-32 | month = Nov | year = 2006 | doi = 10.1136/jcp.2005.031120 | PMID = 17071801 |PMC = 1860509 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/?tool=pubmed }}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
| Line 504: | Line 505: | ||
*PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal | last1 = Zarrin-Khameh | first1 = N. | last2 = Kaye | first2 = KS. | title = Alveolar soft part sarcoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 3 | pages = 488-91 | month = Mar | year = 2007 | doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 | PMID = 17516754 }}</ref> | *PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal | last1 = Zarrin-Khameh | first1 = N. | last2 = Kaye | first2 = KS. | title = Alveolar soft part sarcoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 3 | pages = 488-91 | month = Mar | year = 2007 | doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 | PMID = 17516754 }}</ref> | ||
*PASD +ve (cytoplasmic). | *PASD +ve (cytoplasmic). | ||
===IHC=== | |||
*TFE3 +ve -- suggestive of characteristic translocation. | |||
===Molecular=== | ===Molecular=== | ||
*t(X;17)(p11.2;q25).<ref>{{OMIM|606243}}</ref> | *t(X;17)(p11.2;q25).<ref>{{OMIM|606243}}</ref> | ||
===EM=== | |||
*Distinctive membrane-bound intracytoplasmic crystal lattice with ~5 nm fibres spaced 10 nm apart.<ref name=pmid17071801/> | |||
Image: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig8/ Distinctive crystal lattice in ASPS (nlm.nih.gov)].<ref name=pmid17071801/> | |||
==Desmoplastic small round cell tumour== | ==Desmoplastic small round cell tumour== | ||