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Difference between revisions of "Small round cell tumours"
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| [[Nephroblastoma]] (Wilms tumour) | | [[Nephroblastoma]] (Wilms tumour) | ||
| triphasic - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) | | '''triphasic''' - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) | ||
| kidney lesion, various syndromes | | kidney lesion, various syndromes | ||
| WT-1+ | | WT-1+ | ||
|- | |- | ||
| [[Retinoblastoma]] | | [[Retinoblastoma]] | ||
| Flexner-Wintersteiner [[rosette]] (rosette with empty centre (donut hole))<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | | '''Flexner-Wintersteiner [[rosette]]''' (rosette with empty centre (donut hole))<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
| eye lesion; +/-RB1 gene mutations (familial) | | eye lesion; +/-RB1 gene mutations (familial) | ||
| | | | ||
|- | |- | ||
| [[Medulloblastoma]] | | [[Medulloblastoma]] | ||
| Homer-Wright rosettes ([[rosette]] with a meshwork of fibers (neuropil) at the centre)<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | | '''Homer-Wright rosettes''' ([[rosette]] with a meshwork of fibers (neuropil) at the centre)<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
| +/-[[nevoid basal cell carcinoma syndrome]] | | +/-[[nevoid basal cell carcinoma syndrome]] | ||
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| [[Alveolar rhabdomyosarcoma]] | | [[Alveolar rhabdomyosarcoma]] | ||
| '''alveolar-like spaces''' (small blue cells line spaces supported by fibrous tissue) rhabdomyocytes (eosinophilic cytoplasm +/-cross striations (uncommon), eccentric nucleus) | | '''alveolar-like spaces''' (small blue cells line spaces supported by fibrous tissue), rhabdomyocytes (eosinophilic cytoplasm +/-cross striations (uncommon), eccentric nucleus) | ||
| adolescents, young adults; often mets at presentation | | adolescents, young adults; often mets at presentation | ||
| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
|- | |- | ||
| [[Embryonal rhabdomyosarcoma]]<sup>§</sup> | | [[Embryonal rhabdomyosarcoma]]<sup>§</sup> | ||
| rhabdomyocytes (elongated/cigar-shaped cells, eosinophilic cytoplasm +/-cross striations, eccentric nucleus) | | '''nests with rounded border''', rhabdomyocytes (elongated/cigar-shaped cells, eosinophilic cytoplasm +/-cross striations, eccentric nucleus) | ||
| <10 years old; usu. localized | | <10 years old; usu. localized | ||
| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
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| Small cell carcinoma | | Small cell carcinoma | ||
| | | '''nuclear moulding''', stippled chromatin | ||
| adults, smokers | | adults, smokers | ||
| synaptophysin, chromogranin, CD56, keratins | | synaptophysin, chromogranin, CD56, keratins | ||
|- | |- | ||
| [[Lymphoma]], non-Hogkin's, usu. large cell (e.g. [[DLBCL]]) | | [[Lymphoma]], non-Hogkin's, usu. large cell (e.g. [[DLBCL]]) | ||
| dyscohesive cells, usu. ~2x normal (resting) lymphocyte, usu. nucleolus | | '''dyscohesive cells''', usu. ~2x normal (resting) lymphocyte, usu. nucleolus | ||
| lymphadenopathy (???) | | lymphadenopathy (???) | ||
| CD45 | | CD45 | ||