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Difference between revisions of "Small round cell tumours"
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==General== | ==General== | ||
*Group of tumours that is typically seen in childhood and younger adults. | |||
*Most common small round cell tumour is non-Hodgkin lymphoma.<ref name=pmid23998069/> | |||
===A short differential diagnosis of small round cell tumours=== | ===A short differential diagnosis of small round cell tumours=== | ||
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| nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neuropil (eosinophilic, fluffy, finely vacuolated) | | nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neuropil (eosinophilic, fluffy, finely vacuolated) | ||
| adrenal gland, sympathetic chain; usu. < 3 years old | | adrenal gland, sympathetic chain; usu. < 3 years old | ||
| NB-84+, NSE+, | | NB-84+, NSE+, [[S-100]]- | ||
|- | |- | ||
| [[Nephroblastoma]] (Wilms tumour) | | [[Nephroblastoma]] (Wilms tumour) | ||
| Line 347: | Line 348: | ||
| '''nests with "jigsaw" border''' | | '''nests with "jigsaw" border''' | ||
| peritoneum (abdomen or plevis); male > female; locally invasive | | peritoneum (abdomen or plevis); male > female; locally invasive | ||
| keratin+, EMA+, desmin+ !!! | | [[keratin]]+, [[EMA]]+, desmin+ !!! | ||
|- | |- | ||
| [[Small cell carcinoma]] | | [[Small cell carcinoma]] | ||
| Line 357: | Line 358: | ||
| '''dyscohesive cells''', usu. ~2x normal (resting) lymphocyte, usu. nucleolus | | '''dyscohesive cells''', usu. ~2x normal (resting) lymphocyte, usu. nucleolus | ||
| usu. lymphadenopathy | | usu. lymphadenopathy | ||
| CD45, CD20, TdT, CD3 | | CD45, [[CD20]], TdT, [[CD3]] | ||
|- | |- | ||
|} | |} | ||