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Difference between revisions of "Small round cell tumours"
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[[Image:Ewing sarcoma - very high mag.jpg|thumb|right|[[Micrograph]] showing a small round cell tumour ([[Ewing sarcoma]]) in the lung. [[H&E stain]].]] | [[Image:Ewing sarcoma - very high mag.jpg|thumb|right|[[Micrograph]] showing a small round cell tumour ([[Ewing sarcoma]]) in the lung. [[H&E stain]].]] | ||
'''Small round cell tumours''' (SRCT), also '''small round blue cell tumours''' (SRBCT), are a group of tumours that have a similar histologic appearance. | '''Small round cell tumours''' (SRCT), also '''small round blue cell tumours''' (SRBCT), are a group of tumours that have a similar histologic appearance. | ||
==General== | ==General== | ||
*Group of tumours that is typically seen in childhood and younger adults. | |||
*Most common small round cell tumour is non-Hodgkin lymphoma.<ref name=pmid23998069/> | |||
===A short differential diagnosis of small round cell tumours=== | ===A short differential diagnosis of small round cell tumours=== | ||
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| nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neuropil (eosinophilic, fluffy, finely vacuolated) | | nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neuropil (eosinophilic, fluffy, finely vacuolated) | ||
| adrenal gland, sympathetic chain; usu. < 3 years old | | adrenal gland, sympathetic chain; usu. < 3 years old | ||
| NB-84+, NSE+, | | NB-84+, NSE+, [[S-100]]- | ||
|- | |- | ||
| [[Nephroblastoma]] (Wilms tumour) | | [[Nephroblastoma]] (Wilms tumour) | ||
| Line 347: | Line 348: | ||
| '''nests with "jigsaw" border''' | | '''nests with "jigsaw" border''' | ||
| peritoneum (abdomen or plevis); male > female; locally invasive | | peritoneum (abdomen or plevis); male > female; locally invasive | ||
| keratin+, EMA+, desmin+ !!! | | [[keratin]]+, [[EMA]]+, desmin+ !!! | ||
|- | |- | ||
| [[Small cell carcinoma]] | | [[Small cell carcinoma]] | ||
| Line 357: | Line 358: | ||
| '''dyscohesive cells''', usu. ~2x normal (resting) lymphocyte, usu. nucleolus | | '''dyscohesive cells''', usu. ~2x normal (resting) lymphocyte, usu. nucleolus | ||
| usu. lymphadenopathy | | usu. lymphadenopathy | ||
| CD45, CD20, TdT, CD3 | | CD45, [[CD20]], TdT, [[CD3]] | ||
|- | |- | ||
|} | |} | ||
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| -ve | | -ve | ||
|} | |} | ||
More general panel:<ref name=pmid23998069>{{Cite journal | last1 = D'cruze | first1 = L. | last2 = Dutta | first2 = R. | last3 = Rao | first3 = S. | last4 = R | first4 = A. | last5 = Varadarajan | first5 = S. | last6 = Kuruvilla | first6 = S. | title = The role of immunohistochemistry in the analysis of the spectrum of small round cell tumours at a tertiary care centre. | journal = J Clin Diagn Res | volume = 7 | issue = 7 | pages = 1377-82 | month = Jul | year = 2013 | doi = 10.7860/JCDR/2013/5127.3132 | PMID = 23998069 }}</ref> | |||
*CD45, CD20, CD3, CD99, desmin, EMA, pankeratin, synaptophysin, chromogranin, GFAP. | |||
==See also== | ==See also== | ||