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Difference between revisions of "Small round cell tumours"
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[[Image:Ewing sarcoma - very high mag.jpg|thumb|right|[[Micrograph]] showing a small round cell tumour ([[Ewing sarcoma]]) in the lung. [[H&E stain]].]] | |||
'''Small round cell tumours''' (SRCT), also '''small round blue cell tumours''' (SRBCT), are a group of tumours that have a similar histologic appearance. | '''Small round cell tumours''' (SRCT), also '''small round blue cell tumours''' (SRBCT), are a group of tumours that have a similar histologic appearance. | ||
==General== | ==General== | ||
*Group of tumours that is typically seen in childhood and younger adults. | |||
*Most common small round cell tumour is non-Hodgkin lymphoma.<ref name=pmid23998069/> | |||
===A short | ===A short differential diagnosis of small round cell tumours=== | ||
A short DDx of SRCTs:<ref>URL: [http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm]. Accessed on: 2 July 2010.</ref><ref>{{cite journal |author=Chen QR, Vansant G, Oades K, ''et al.'' |title=Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction |journal=J Mol Diagn |volume=9 |issue=1 |pages=80–8 |year=2007 |month=February |pmid=17251339 |pmc=1867426 |doi=10.2353/jmoldx.2007.060111 |url=}}</ref> | A short DDx of SRCTs:<ref>URL: [http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm]. Accessed on: 2 July 2010.</ref><ref>{{cite journal |author=Chen QR, Vansant G, Oades K, ''et al.'' |title=Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction |journal=J Mol Diagn |volume=9 |issue=1 |pages=80–8 |year=2007 |month=February |pmid=17251339 |pmc=1867426 |doi=10.2353/jmoldx.2007.060111 |url=}}</ref> | ||
*[[Neuroblastoma]]. | *[[Neuroblastoma]]. | ||
| Line 22: | Line 24: | ||
Memory device: 4 -blastomas (hepato-, neuro-, nephro-, retino-), PNET/Ewing sarcoma (medulloblastoma), LADSSS (lymphoma, alveolar rhabdomyosarcoma, DSRCT, small cell carcinoma, small cell osteosarcoma, synovial sarcoma). | Memory device: 4 -blastomas (hepato-, neuro-, nephro-, retino-), PNET/Ewing sarcoma (medulloblastoma), LADSSS (lymphoma, alveolar rhabdomyosarcoma, DSRCT, small cell carcinoma, small cell osteosarcoma, synovial sarcoma). | ||
===A long | ===A long differential diagnosis of small blue cell tumours=== | ||
Adapted from ''Miller'' with modifications:<ref name=miller>Miller RT. (Sep 2013). ''Atlantic Diagnostic Immunohistochemistry Symposium''. St. John's, NL, Canada.</ref> | |||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
! Tumour | ! Tumour | ||
| Line 260: | Line 263: | ||
| | | | ||
|- | |- | ||
| [[Small cell angiosarcoma]] | | [[angiosarcoma|Small cell angiosarcoma]] | ||
| vascular lesions | | vascular lesions | ||
| | | | ||
| Line 310: | Line 313: | ||
| nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neuropil (eosinophilic, fluffy, finely vacuolated) | | nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neuropil (eosinophilic, fluffy, finely vacuolated) | ||
| adrenal gland, sympathetic chain; usu. < 3 years old | | adrenal gland, sympathetic chain; usu. < 3 years old | ||
| NB-84+, NSE+, | | NB-84+, NSE+, [[S-100]]- | ||
|- | |- | ||
| [[Nephroblastoma]] (Wilms tumour) | | [[Nephroblastoma]] (Wilms tumour) | ||
| Line 345: | Line 348: | ||
| '''nests with "jigsaw" border''' | | '''nests with "jigsaw" border''' | ||
| peritoneum (abdomen or plevis); male > female; locally invasive | | peritoneum (abdomen or plevis); male > female; locally invasive | ||
| keratin+, EMA+, desmin+ !!! | | [[keratin]]+, [[EMA]]+, desmin+ !!! | ||
|- | |- | ||
| [[Small cell carcinoma]] | | [[Small cell carcinoma]] | ||
| Line 355: | Line 358: | ||
| '''dyscohesive cells''', usu. ~2x normal (resting) lymphocyte, usu. nucleolus | | '''dyscohesive cells''', usu. ~2x normal (resting) lymphocyte, usu. nucleolus | ||
| usu. lymphadenopathy | | usu. lymphadenopathy | ||
| CD45, CD20, TdT, CD3 | | CD45, [[CD20]], TdT, [[CD3]] | ||
|- | |- | ||
|} | |} | ||
| Line 399: | Line 402: | ||
| -ve | | -ve | ||
|} | |} | ||
More general panel:<ref name=pmid23998069>{{Cite journal | last1 = D'cruze | first1 = L. | last2 = Dutta | first2 = R. | last3 = Rao | first3 = S. | last4 = R | first4 = A. | last5 = Varadarajan | first5 = S. | last6 = Kuruvilla | first6 = S. | title = The role of immunohistochemistry in the analysis of the spectrum of small round cell tumours at a tertiary care centre. | journal = J Clin Diagn Res | volume = 7 | issue = 7 | pages = 1377-82 | month = Jul | year = 2013 | doi = 10.7860/JCDR/2013/5127.3132 | PMID = 23998069 }}</ref> | |||
*CD45, CD20, CD3, CD99, desmin, EMA, pankeratin, synaptophysin, chromogranin, GFAP. | |||
==See also== | ==See also== | ||