Difference between revisions of "Small intestine"

Jump to navigation Jump to search

Small intestine (view source)

Revision as of 16:07, 18 November 2022

3,366 bytes removed ,  16:07, 18 November 2022
+ileitis
(+ileitis)
 
(17 intermediate revisions by the same user not shown)
Line 27: Line 27:


===Sign out===
===Sign out===
<pre>
Small Bowel, Biopsy:
- Small bowel mucosa within normal limits.
</pre>
<pre>
Terminal Ileum, Biopsy:
- Small bowel mucosa within normal limits.
</pre>
<pre>
Terminal Ileum, Biopsy:
- Small bowel mucosa with morphologically benign lymphoid aggregates, negative for significant pathology.
</pre>
====Roux-en-Y gastric bypass====
{{Main|Obese}}
{{Main|Roux-en-Y gastric bypass}}
====Block letters====
<pre>
<pre>
SMALL BOWEL, BIOPSY:
SMALL BOWEL, BIOPSY:
Line 61: Line 81:
**[[Crohn's disease]] and[[ulcerative colitis]] are discussed in their respective articles.
**[[Crohn's disease]] and[[ulcerative colitis]] are discussed in their respective articles.


=Specific conditions=
=Specific diagnoses=
==Small bowel obstruction==
==Ileitis==
*Abbreviated ''SBO''.
:''Active ileitis'' and ''acute ileitis'' redirect here.
:This section gives an overview of SBOs. Its primary focus is benign causes of SBO that have nonspecific pathologic findings. Specific causes definitively identified by pathology, e.g. [[adenocarcinoma]], are dealt with separately.
:This deals with nonspecific ileitis.
===General===
===General===
*Radiologic/[[clinical diagnosis]].
*Common.
 
The usual causes of bowel obstruction (large & small) are (mnemonic) ''SHAVING'':
*Strictures (think [[IBD]]).
*Hernias.
*Adhesions.
*[[Volvulus]].
*Intussusception.
*Neoplasia.
*Gallstone ileus.
 
The top three are:<ref>URL: [http://www.emedicine.com/EMERG/topic66.htm http://www.emedicine.com/EMERG/topic66.htm]. Accessed on: 19 April 2011.</ref><ref>{{Ref TN2007 |GS21}}</ref>
* Adhesions > hernias > neoplasms.
 
In the context of bowel obstructions and IBD, pathologists often see resected [[stoma]]s (that were put in place emergently).  These specimens are usually fairly straight forward.
 
===Radiology===
*Air-fluid levels.
 
===Gross===
*+/-Adhesions.
*+/-Bowel contorted.
*+/-Luminal narrowing +/-proximal dilation.
*+/-Serosal exudate.
**Suggestive of perforation.


===Microscopic===
===Microscopic===
Features:
Features:
*+/-Adhesions (serosal).
*Intraepithelial [[neutrophil]]s.
**Dense fibrous tissue replaces the adipose tissue.
**+/-Increased vascularity.
*+/-Submucosal fibrosis.
*+/-[[Serositis]] - seen in small bowel perforation.
*+/-Foreign body-type granuloma - due to previous surgical intervention.


DDx:
DDx:
*Small bowel [[adenocarcinoma]] - most important differential diagnosis.
*[[Crohn's disease]].
*Metastatic adenocarcinoma - classically on the serosal aspect.
*Infectious ileitis.
*[[Signet ring cell carcinoma]].
**[[Tuberculosis]].
*Benign ileum - may have focal intra-epithelial lymphocytes associated with lamina propria lymphoid nodules.
*[[NSAID enteropathy]].<ref name=pmid20532706>{{Cite journal  | last1 = Dilauro | first1 = S. | last2 = Crum-Cianflone | first2 = NF. | title = Ileitis: when it is not Crohn's disease. | journal = Curr Gastroenterol Rep | volume = 12 | issue = 4 | pages = 249-58 | month = Aug | year = 2010 | doi = 10.1007/s11894-010-0112-5 | PMID = 20532706 }}</ref>
 
====Images====
<gallery>
Image: Mild ileitis -- very low mag.jpg | Ileitis - very low mag. (WC)
Image: Mild ileitis -- low mag.jpg | Ileitis - low mag. (WC)
Image: Mild ileitis -- intermed mag.jpg | Ileitis - intermed. mag. (WC)
Image: Mild ileitis -- high mag.jpg | Ileitis - high mag. (WC)
</gallery>


===Sign out===
===Sign out===
<pre>
<pre>
SMALL BOWEL, RESECTION:
Terminal Ileum, Biopsy:
- SMALL BOWEL WITH FIBROUS ADHESIONS (EXTENSIVE) ASSOCIATED WITH FOCAL LUMINAL
- Small bowel with moderate active inflammation, marked villous blunting, basal plasmacytosis
   NARROWING.
   and prominent eosinophils, see comment.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
- NEGATIVE for granulomas.
</pre>
- NEGATIVE for dysplasia.


<pre>
Comment:
SMALL BOWEL, RESECTION:
The inflammation is nonspecific; it could be due to infection, inflammatory bowel disease (especially Crohn's disease), ischemia, or therapy/drugs. Clinical correlation is required.
- SMALL BOWEL WITH FIBROUS ADHESIONS (EXTENSIVE), FOCAL LUMINAL NARROWING AND A
  FOREIGN BODY-TYPE GRANULOMA.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
</pre>
</pre>


====Ischemic changes====
==Small bowel obstruction==
<pre>
*Abbreviated ''SBO''.
SMALL BOWEL, RESECTION:
{{Main|Small bowel obstruction}}
- SMALL BOWEL WITH ISCHEMIC CHANGES, FIBROUS ADHESIONS, FOCAL SEROSITIS AND MURAL
  MICROABSCESS FORMATION.
- NO SIGNIFICANT VASCULAR PATHOLOGY APPARENT.
- NEGATIVE FOR MALIGNANCY.
</pre>


==Small bowel neoplasms==
==Small bowel neoplasms==
Line 163: Line 156:


===IHC===
===IHC===
*CD20 and CD3 - mixed population of lymphocytes.
*[[CD20]] and CD3 - mixed population of lymphocytes.
*[[CD23]] - follicular dendritic cells.
*[[CD23]] - follicular dendritic cells.
*Cyclin D1 -ve.
*Cyclin D1 -ve.
Line 223: Line 216:


DDx:
DDx:
*Cryptogenic multifocal ulcerous stenosing enteritis.<ref>{{Cite journal  | last1 = Chung | first1 = SH. | last2 = Jo | first2 = Y. | last3 = Ryu | first3 = SR. | last4 = Ahn | first4 = SB. | last5 = Son | first5 = BK. | last6 = Kim | first6 = SH. | last7 = Park | first7 = YS. | last8 = Hong | first8 = YO. | title = Diaphragm disease compared with cryptogenic multifocal ulcerous stenosing enteritis. | journal = World J Gastroenterol | volume = 17 | issue = 23 | pages = 2873-6 | month = Jun | year = 2011 | doi = 10.3748/wjg.v17.i23.2873 | PMID = 21734797 }}</ref> (???)
*[[Crohn's disease]].
*[[Crohn's disease]].


==Meckel diverticulum==
==Meckel diverticulum==
===General===
{{Main|Meckel diverticulum}}
*Most common congenital anomaly of the gastrointestinal tract.<ref name=pmid15026601>{{Cite journal  | last1 = Levy | first1 = AD. | last2 = Hobbs | first2 = CM. | title = From the archives of the AFIP. Meckel diverticulum: radiologic features with pathologic Correlation. | journal = Radiographics | volume = 24 | issue = 2 | pages = 565-87 | month =  | year =  | doi = 10.1148/rg.242035187 | PMID = 15026601 }}</ref>
**Remnant of the ''omphalomesenteric duct'' - a connection of the yolk sac and midgut.
 
The rule of 2s:
*2 feet from the terminal ileum
*2% of the population
*2% symptomatic.
*2 inches long.
*2 year old.
*2 types of epithelium - gastric and pancreatic.
 
Main clinical DDx of a symptomatic Meckel diverticulum:
*[[Appendicitis]].
 
===Gross===
*Antimesenteric attachement, i.e. a ''Meckel's diverticulum'' hangs off the side opposite of the mesentery.
 
Image:
*[http://commons.wikimedia.org/wiki/File:Meckel%27s_Diverticulum_AFIP.jpg Meckel diverticulum - (AFIP/WC)].
 
===Microscopic===
Features:<ref name=pmid15026601/>
*Small bowel mucosa.
*+/-Gastric mucosa:
**Foveolar epithelium: champagne flute-like columnar epithelium.
**Oxyntic mucosa: parietal cells (pink) and chief cells (purple).
*+/-Pancreatic epithelium:
**Pancreatic acini.
 
Images:
*[http://radiographics.rsna.org/content/24/2/565/F12.expansion.html Gastric foveolar epithelium in a MD (radiographics.rsna.org)].
*[http://radiographics.rsna.org/content/24/2/565/F15.expansion.html Gastric glands in a MD (radiographics.rsna.org)].
*[http://radiographics.rsna.org/content/24/2/565.long Pancreatic glands in a MD (radiographics.rsna.org)].


==Ischemic enteritis==
==Ischemic enteritis==
===General===
{{Main|Ischemic enteritis}}
*Typically elderly and due to [[atherosclerosis]].
*Rare.
*High mortality.<ref name=pmid18616124>{{Cite journal  | last1 = Nakase | first1 = H. | title = [Ischemic enteritis]. | journal = Nihon Rinsho | volume = 66 | issue = 7 | pages = 1330-4 | month = Jul | year = 2008 | doi =  | PMID = 18616124 }}</ref>
*May occur together with ischemia of the colon, i.e. ''[[ischemic colitis]]'', in which case it is known as ''ischemic enterocolitis''.
 
Etiologies:
*[[Atherosclerosis]].
*[[Vasculitis]].
*Embolism.
*Thrombosis.
 
===Microscopic===
Features:
*See ''[[ischemic colitis]]''.
 
DDx:
*Infection.
*[[Crohn's disease]].
*[[Radiation changes]].
*Drugs/toxins.


=Weird stuff=
=Weird stuff=
==Autoimmune enteropathy==
==Autoimmune enteropathy==
*Abbreviated as ''AIE''.
*Abbreviated as ''AIE''.
===General===
{{Main|Autoimmune enteropathy}}
*Considered a pediatric disease.
*Super rare in adults - there are only ~11 reported cases in the literature.<ref name=pmid17683994>{{Cite journal  | last1 = Akram | first1 = S. | last2 = Murray | first2 = JA. | last3 = Pardi | first3 = DS. | last4 = Alexander | first4 = GL. | last5 = Schaffner | first5 = JA. | last6 = Russo | first6 = PA. | last7 = Abraham | first7 = SC. | title = Adult autoimmune enteropathy: Mayo Clinic Rochester experience. | journal = Clin Gastroenterol Hepatol | volume = 5 | issue = 11 | pages = 1282-90; quiz 1245 | month = Nov | year = 2007 | doi = 10.1016/j.cgh.2007.05.013 | PMID = 17683994 | PMC = 2128725 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128725/ }}</ref>
*May be a component of the IPEX syndrome.<ref>{{Cite journal  | last1 = Gentile | first1 = NM. | last2 = Murray | first2 = JA. | last3 = Pardi | first3 = DS. | title = Autoimmune enteropathy: a review and update of clinical management. | journal = Curr Gastroenterol Rep | volume = 14 | issue = 5 | pages = 380-5 | month = Oct | year = 2012 | doi = 10.1007/s11894-012-0276-2 | PMID = 22810979 }}</ref>
 
Diagnosis is clinico-pathologic:<ref name=pmid17683994/>
#Intact immune system.
#Autoantibodies.
#*Anti-enterocyte antibody.
#*Anti-goblet antibody.
#Lack of response to gluten-free diet.
 
===Microscopic===
Features:<ref name=pmid17683994/>
*+/-Loss of goblet cells.
*+/-Loss of paneth cells.
*Villous blunting.
 
DDx:
*[[Celiac disease]].


=See also=
=See also=
Michael
48,466

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/33297...52225"

Navigation menu