48,436
edits
Difference between revisions of "Small cell carcinoma of the prostate gland"
Jump to navigation
Jump to search
Small cell carcinoma of the prostate gland (view source)
Revision as of 16:33, 19 March 2018
, 16:33, 19 March 2018no edit summary
| (9 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Prostate carcinoma with NEC -- high mag.jpg | |||
| Width = | |||
| Caption = Small cell carcinoma of the prostate. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = small cells with nuclear moulding, stippled chromatin and high [[NC ratio]], +/-high-grade acinar adenocarcinoma (common) | |||
| Subtypes = | |||
| LMDDx = [[small cell carcinoma of the urinary bladder]], metastatic [[small cell carcinoma]], poorly differentiated [[prostate carcinoma]] | |||
| Stains = | |||
| IHC = chromogranin A +ve, PSA -ve/+ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]] | |||
| Staging = [[prostate cancer staging]] | |||
| Site = [[prostate gland]] - see ''[[prostate cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = [[PSA]] low (in relation to conventional cancer) | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = other types of [[prostate cancer]], metastatic cancer | |||
| Tx = chemotherapy | |||
}} | |||
'''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course. | '''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course. | ||
The more general topic of ''[[prostate cancer with neuroendocrine differentiation]]'' is dealt with in a separate article. | |||
==General== | ==General== | ||
| Line 6: | Line 40: | ||
*Poor prognosis. | *Poor prognosis. | ||
*Not [[prostate cancer grading|graded]] ([[ISUP]] 2005 consensus on [[Gleason grading system]]<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref>). | *Not [[prostate cancer grading|graded]] ([[ISUP]] 2005 consensus on [[Gleason grading system]]<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref>). | ||
Clinical: | |||
*PSA often low in comparison to conventional prostate cancer.<ref name=pmid22110988/> | |||
==Microscopic== | ==Microscopic== | ||
| Line 23: | Line 60: | ||
*[[Small cell carcinoma of the urinary bladder]]. | *[[Small cell carcinoma of the urinary bladder]]. | ||
*[[Lymphoma]], large cell. | *[[Lymphoma]], large cell. | ||
*[[Prostate carcinoma with amphicrine features]] - also have [[AR]] staining.<ref name=pmid28756619>{{Cite journal | last1 = Prendeville | first1 = S. | last2 = Al-Bozom | first2 = I. | last3 = Compérat | first3 = E. | last4 = Sweet | first4 = J. | last5 = Evans | first5 = AJ. | last6 = Ben-Gashir | first6 = M. | last7 = Mete | first7 = O. | last8 = van der Kwast | first8 = TH. | last9 = Downes | first9 = MR. | title = Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin? | journal = Histopathology | volume = 71 | issue = 6 | pages = 926-933 | month = Dec | year = 2017 | doi = 10.1111/his.13330 | PMID = 28756619 }}</ref> | |||
*Other [[small round cell tumours]]. | *Other [[small round cell tumours]]. | ||
===Images=== | ===Images=== | ||
====Case==== | |||
<gallery> | |||
Image: Prostate carcinoma with NEC -- very low mag.jpg | PCNEC - very low mag. (WC) | |||
Image: Prostate carcinoma with NEC -- low mag.jpg | PCNEC - low mag. (WC) | |||
Image: Prostate carcinoma with NEC -- intermed mag.jpg | PCNEC - intermed. mag. (WC) | |||
Image: Prostate carcinoma with NEC -- high mag.jpg | PCNEC - high mag. (WC) | |||
Image: Prostate carcinoma with NEC - conv only -- low mag.jpg | PCNEC - low mag. (WC) | |||
Image: Prostate carcinoma with NEC - conv only -- intermed mag.jpg | PCNEC - intermed. mag. (WC) | |||
Image: Prostate carcinoma with NEC - conv only -- high mag.jpg | PCNEC - high mag. (WC) | |||
</gallery> | |||
====www==== | ====www==== | ||
*[http://www.webpathology.com/image.asp?case=23&n=25 SmCC of the prostate - low mag. (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=23&n=25 SmCC of the prostate - low mag. (webpathology.com)]. | ||
| Line 39: | Line 88: | ||
==See also== | ==See also== | ||
*[[Prostate cancer]]. | *[[Prostate cancer]]. | ||
*[[Small cell carcinoma]]. | |||
*[[Paneth cell-like change of the prostate gland]]. | |||
==References== | ==References== | ||