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'''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course. | |||
==General== | |||
*Very rare.<ref name=pmid22110988>{{Cite journal | last1 = Furtado | first1 = P. | last2 = Lima | first2 = MV. | last3 = Nogueira | first3 = C. | last4 = Franco | first4 = M. | last5 = Tavora | first5 = F. | title = Review of small cell carcinomas of the prostate. | journal = Prostate Cancer | volume = 2011 | issue = | pages = 543272 | month = | year = 2011 | doi = 10.1155/2011/543272 | PMID = 22110988 }}</ref> | |||
*Most common small cell carcinoma outside of the lung.<ref name=pmid22110988/> | |||
*Poor prognosis. | |||
*Not graded (ISUP 2005 consensus on [[Gleason score]]<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref>). | |||
==Microscopic== | |||
Features: | |||
*Small cells with: | |||
**Nuclear moulding. | |||
**Stippled chromatin. | |||
**High [[NC ratio]]. | |||
*+/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.<ref name=pmid22110988/> | |||
Notes: | |||
*Similar to [[small cell carcinoma of the lung]]. | |||
*High-grade squamoid component favours metastatic [[urothelial carcinoma]]. | |||
**UCC usu. HWCK +ve. | |||
DDx: | |||
*[[Small cell carcinoma of the urinary bladder]]. | |||
*[[Lymphoma]], large cell. | |||
*Other [[small round cell tumours]]. | |||
===Images=== | |||
====www==== | |||
*[http://www.webpathology.com/image.asp?case=23&n=25 SmCC of the prostate - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=23&n=26 SmCC of the prostate - high mag. (webpathology.com)]. | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200299/figure/fig1/ SmCC of the prostate - low mag. (nih.gov)]. | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200299/figure/fig3/ SmCC of the prostate - high mag. (nih.gov)]. | |||
==IHC== | |||
Features:<ref name=pmid22110988/> | |||
*PSA weak +ve/-ve. | |||
*Chromogranin +ve. | |||
==See also== | |||
*[[Prostate cancer]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Prostate carcinoma]] |
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