Difference between revisions of "Small cell carcinoma"

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Small cell carcinoma (view source)

Revision as of 13:12, 26 April 2016

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[[Image:Small_cell_lung_cancer_-_cytology.jpg |thumb|300px|[[Micrograph]] showing a small cell carcinoma.]]
[[Image:Small cell carcinoma in lymph node -- very high mag.jpg |thumb|300px|[[Micrograph]] showing a small cell carcinoma.]]
'''Small cell carcinoma''' is a type of carcinoma.  It is mostly commonly from the [[lung tumours|lung]]; 95% of cases are from the lung.<ref name=pmid21618245/>   
'''Small cell carcinoma''' is a type of carcinoma.  It is mostly commonly from the [[lung tumours|lung]]; 95% of cases are from the lung.<ref name=pmid21618245/>   


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*Breast.<ref name=pmid21657157>{{Cite journal  | last1 = Cesaretti | first1 = M. | last2 = Guarnieri | first2 = A. | last3 = Gaggelli | first3 = I. | last4 = Tirone | first4 = A. | last5 = Francioli | first5 = N. | last6 = Carli | first6 = AF. | title = Small cell carcinoma of the breast. Report of a case. | journal = Ann Ital Chir | volume = 82 | issue = 1 | pages = 61-4 | month =  | year =  | doi =  | PMID = 21657157 }}</ref>
*Breast.<ref name=pmid21657157>{{Cite journal  | last1 = Cesaretti | first1 = M. | last2 = Guarnieri | first2 = A. | last3 = Gaggelli | first3 = I. | last4 = Tirone | first4 = A. | last5 = Francioli | first5 = N. | last6 = Carli | first6 = AF. | title = Small cell carcinoma of the breast. Report of a case. | journal = Ann Ital Chir | volume = 82 | issue = 1 | pages = 61-4 | month =  | year =  | doi =  | PMID = 21657157 }}</ref>
*Thyroid gland.<ref name=pmid21644012>{{Cite journal  | last1 = Beach | first1 = DF. | last2 = Klump | first2 = WJ. | last3 = Haddad | first3 = G. | last4 = Reid | first4 = LM. | last5 = Schwarting | first5 = R. | last6 = Hageboutros | first6 = A. | title = Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. | journal = Med Oncol | volume =  | issue =  | pages =  | month = Jun | year = 2011 | doi = 10.1007/s12032-011-9996-7 | PMID = 21644012 }}</ref>
*Thyroid gland.<ref name=pmid21644012>{{Cite journal  | last1 = Beach | first1 = DF. | last2 = Klump | first2 = WJ. | last3 = Haddad | first3 = G. | last4 = Reid | first4 = LM. | last5 = Schwarting | first5 = R. | last6 = Hageboutros | first6 = A. | title = Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. | journal = Med Oncol | volume =  | issue =  | pages =  | month = Jun | year = 2011 | doi = 10.1007/s12032-011-9996-7 | PMID = 21644012 }}</ref>
*Liver.<ref name=pmid19669327>{{Cite journal  | last1 = Morikawa | first1 = H. | last2 = Nakayama | first2 = Y. | last3 = Maeda | first3 = T. | last4 = Nadatani | first4 = Y. | last5 = Kobayashi | first5 = S. | last6 = Iwai | first6 = S. | last7 = Enomoto | first7 = M. | last8 = Tamori | first8 = A. | last9 = Sakaguchi | first9 = H. | title = A case of primary small cell carcinoma of the liver that was treated with chemotherapy. | journal = Hepatol Int | volume = 2 | issue = 4 | pages = 500-4 | month = Dec | year = 2008 | doi = 10.1007/s12072-008-9090-1 | PMID = 19669327 }}</ref><ref name=pmid18159605>{{Cite journal  | last1 = Choi | first1 = SJ. | last2 = Kim | first2 = JM. | last3 = Han | first3 = JY. | last4 = Ahn | first4 = SI. | last5 = Kim | first5 = JS. | last6 = Kim | first6 = L. | last7 = Park | first7 = IS. | last8 = Chu | first8 = YC. | title = Extrapulmonary small cell carcinoma of the liver: clinicopathological and immunohistochemical findings. | journal = Yonsei Med J | volume = 48 | issue = 6 | pages = 1066-71 | month = Dec | year = 2007 | doi = 10.3349/ymj.2007.48.6.1066 | PMID = 18159605 }}</ref>


==General==
==General==
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*Large cell [[lymphoma]]s, e.g. [[DLBCL]], [[ALCL]].
*Large cell [[lymphoma]]s, e.g. [[DLBCL]], [[ALCL]].
*[[Chloroma]].
*[[Chloroma]].
*[[Rhabdomyosarcoma]] - usu. [[CD56]] positive, may be keratin positive and positive for other neuroendocrine markers.<ref name=pmid18487991>{{Cite journal  | last1 = Bahrami | first1 = A. | last2 = Gown | first2 = AM. | last3 = Baird | first3 = GS. | last4 = Hicks | first4 = MJ. | last5 = Folpe | first5 = AL. | title = Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall. | journal = Mod Pathol | volume = 21 | issue = 7 | pages = 795-806 | month = Jul | year = 2008 | doi = 10.1038/modpathol.2008.86 | PMID = 18487991 }}</ref>
*[[Rhabdomyosarcoma]] - usu. [[CD56]] positive, may be keratin positive and positive for other [[neuroendocrine markers]].<ref name=pmid18487991>{{Cite journal  | last1 = Bahrami | first1 = A. | last2 = Gown | first2 = AM. | last3 = Baird | first3 = GS. | last4 = Hicks | first4 = MJ. | last5 = Folpe | first5 = AL. | title = Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall. | journal = Mod Pathol | volume = 21 | issue = 7 | pages = 795-806 | month = Jul | year = 2008 | doi = 10.1038/modpathol.2008.86 | PMID = 18487991 }}</ref>
*[[Atypical lung carcinoid tumour]] (lung only).
*[[Typical lung carcinoid tumour]] (lung only).
*Other [[small round cell tumours]].
*Other [[small round cell tumours]].


===Images===
===Images===
www:
====Cytology====
*[http://networks.lww.com/pathology/blog/iow/pages/post.aspx?PostID=55 Small cell carcinoma in a lymph node (lww.com)].
<gallery>
Image:Small_cell_lung_cancer_-_cytology.jpg | Small cell carcinoma - cytology - Field stain. (WC)
Image: Lung small cell carcinoma - Diff-Quik -- high mag.jpg | SmCC - Diff-Quik - high mag. (WC)
Image: Lung small cell carcinoma - Diff-Quik -- very high mag.jpg | SmCC - Diff-Quik - very high mag. (WC)
Image: Lung small cell carcinoma - Diff-Quik -- extremely high mag.jpg | SmCC - Diff-Quik - extremely high mag. (WC)
Image: Lung small cell carcinoma -- very high mag.jpg | SmCC - Pap stain - very high mag. (WC)
Image: Lung small cell carcinoma -- extremely high mag.jpg | SmCC - Pap stain - extremely high mag. (WC)
</gallery>
 
====Metastatic====
<gallery>
<gallery>
Image:Small_cell_lung_cancer_-_cytology.jpg | Small cell carcinoma - cytology (WC)
Image:Metastatic_small_cell_carcinoma_-_high_mag.jpg | Metastatic small cell carcinoma - high mag. (WC)
Image:Metastatic_small_cell_carcinoma_-_high_mag.jpg | Metastatic small cell carcinoma - high mag. (WC)
Image:Metastatic_small_cell_carcinoma_-_very_high_mag.jpg | Metastatic small cell carcinoma - very high mag. (WC)
Image:Metastatic_small_cell_carcinoma_-_very_high_mag.jpg | Metastatic small cell carcinoma - very high mag. (WC)
</gallery>
</gallery>
====Small cell carcinoma in a lymph node====
<gallery>
Image: Small cell carcinoma in lymph node -- low mag.jpg | Small cell carcinoma in a lymph node - low mag. (WC)
Image: Small cell carcinoma in lymph node -- intermed mag.jpg | Small cell carcinoma in a lymph node - intermed. mag. (WC)
Image: Small cell carcinoma in lymph node -- high mag.jpg | Small cell carcinoma in a lymph node - high mag. (WC)
Image: Small cell carcinoma in lymph node -- very high mag.jpg | Small cell carcinoma in a lymph node - very high mag. (WC)
</gallery>
==IHC==
*[[Neuroendocrine markers]] +ve - confirm the diagnosis.
*IHC not particularity useful for determination of the primary site.<ref name=pmid17270664>{{Cite journal  | last1 = Lobins | first1 = R. | last2 = Floyd | first2 = J. | title = Small cell carcinoma of unknown primary. | journal = Semin Oncol | volume = 34 | issue = 1 | pages = 39-42 | month = Feb | year = 2007 | doi = 10.1053/j.seminoncol.2006.10.027 | PMID = 17270664 }}</ref> ‡
Note:
*‡ A CT chest should be done to assess for a lung tumour; fortunately, lung small cell carcinoma and extrapulmonary small cell cancer are treated similarily.<ref name=pmid20052730>{{Cite journal  | last1 = Brennan | first1 = SM. | last2 = Gregory | first2 = DL. | last3 = Stillie | first3 = A. | last4 = Herschtal | first4 = A. | last5 = Mac Manus | first5 = M. | last6 = Ball | first6 = DL. | title = Should extrapulmonary small cell cancer be managed like small cell lung cancer? | journal = Cancer | volume = 116 | issue = 4 | pages = 888-95 | month = Feb | year = 2010 | doi = 10.1002/cncr.24858 | PMID = 20052730 }}</ref>


==See also==
==See also==
Michael
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