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Difference between revisions of "Sjögren syndrome"
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The syndrome may be part of another [[connective tissue disorder]], e.g. [[rheumatoid arthritis]], in which case it is called ''secondary Sjögren syndrome''.<ref name=pmid1703737>{{Cite journal | last1 = Celenligil | first1 = H. | last2 = Kansu | first2 = E. | last3 = Ruacan | first3 = S. | last4 = Eratalay | first4 = K. | last5 = Irkeç | first5 = M. | title = Characterization of peripheral blood and salivary gland lymphocytes in secondary Sjögren's syndrome. | journal = Ann Dent | volume = 49 | issue = 2 | pages = 18-22 | month = | year = 1990 | doi = | PMID = 1703737 }}</ref> | The syndrome may be part of another [[connective tissue disorder]], e.g. [[rheumatoid arthritis]], in which case it is called ''secondary Sjögren syndrome''.<ref name=pmid1703737>{{Cite journal | last1 = Celenligil | first1 = H. | last2 = Kansu | first2 = E. | last3 = Ruacan | first3 = S. | last4 = Eratalay | first4 = K. | last5 = Irkeç | first5 = M. | title = Characterization of peripheral blood and salivary gland lymphocytes in secondary Sjögren's syndrome. | journal = Ann Dent | volume = 49 | issue = 2 | pages = 18-22 | month = | year = 1990 | doi = | PMID = 1703737 }}</ref> | ||
Pathologists are likely to this condition as a ''[[labial salivary gland]]'' biopsy. | Pathologists are likely to see this condition as a ''[[labial salivary gland]]'' biopsy. | ||
''Lip biopsy'' redirects here. | |||
==General== | ==General== | ||
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Calculating the focus score (fs): | Calculating the focus score (fs): | ||
# Count the significant foci (n). | # Count the significant foci (n). | ||
# Estimate | # Estimate the sample area in mm<sup>2</sup> (a). | ||
:<math>fs = { n \over a } \times 4 \ mm</math> | :<math>fs = { n \over a } \times 4 \ mm^2</math> | ||
====Grading==== | ====Grading==== | ||
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==Sign out== | ==Sign out== | ||
===Suggestive=== | |||
<pre> | <pre> | ||
LOWER LIP, BIOPSY: | LOWER LIP, BIOPSY: | ||
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This result needs to be combined with the clinical and serologic criteria used | This result needs to be combined with the clinical and serologic criteria used | ||
to diagnose Sjoegren's disease. | to diagnose Sjoegren's disease. | ||
</pre> | |||
===Not suggestive=== | |||
<pre> | |||
Minor Salivary Gland, Biopsy: | |||
- Benign minor salivary gland with one focus of chronic lymphocyte | |||
predominant inflammation. | |||
- Focus score less than one; not suggestive of Sjoegren's disease. | |||
Comment: | |||
Estimated area of salivary gland: 50 mm*mm. | |||
Number of foci (~50 lymphocytes): 1. | |||
Plasma cells: few (<10%). | |||
Fibrosis: none/minimal. | |||
Focus score (number of foci / area x 4 mm*mm) = < 1. | |||
The findings do not exclude Sjoegren's disease. Clinical and serologic | |||
correlation is required. | |||
</pre> | </pre> | ||