Difference between revisions of "Sinus histiocytosis"
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*Benign. | *Benign. | ||
*Non-specific finding. | *Non-specific finding. | ||
*Frequently associated with infections and neoplasia.<ref name=pmid18504582>{{Cite journal | last1 = Hartmann | first1 = S. | last2 = Kriener | first2 = S. | last3 = Hansmann | first3 = ML. | title = [Diagnostic spectrum of reactive lymph node changes]. | journal = Pathologe | volume = 29 | issue = 4 | pages = 253-63 | month = Jul | year = 2008 | doi = 10.1007/s00292-008-1003-5 | PMID = 18504582 }}</ref> | |||
*Reported in association with hip replacements.<ref name=pmid8279630>{{Cite journal | last1 = Albores-Saavedra | first1 = J. | last2 = Vuitch | first2 = F. | last3 = Delgado | first3 = R. | last4 = Wiley | first4 = E. | last5 = Hagler | first5 = H. | title = Sinus histiocytosis of pelvic lymph nodes after hip replacement. A histiocytic proliferation induced by cobalt-chromium and titanium. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 83-90 | month = Jan | year = 1994 | doi = | PMID = 8279630 }} | *Reported in association with hip replacements.<ref name=pmid8279630>{{Cite journal | last1 = Albores-Saavedra | first1 = J. | last2 = Vuitch | first2 = F. | last3 = Delgado | first3 = R. | last4 = Wiley | first4 = E. | last5 = Hagler | first5 = H. | title = Sinus histiocytosis of pelvic lymph nodes after hip replacement. A histiocytic proliferation induced by cobalt-chromium and titanium. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 83-90 | month = Jan | year = 1994 | doi = | PMID = 8279630 }} | ||
</ref> | </ref> | ||
==Gross== | |||
*+/-Enlargement of lymph node.<ref name=pmid2051659>{{Cite journal | last1 = Saito | first1 = T. | last2 = Kuwahara | first2 = A. | last3 = Kaketani | first3 = K. | last4 = Hirao | first4 = E. | last5 = Miyahara | first5 = M. | last6 = Shimoda | first6 = K. | last7 = Kobayashi | first7 = M. | title = Preoperative assessment of cervical lymph node involvement in esophageal cancer. | journal = Jpn J Surg | volume = 21 | issue = 2 | pages = 145-53 | month = Mar | year = 1991 | doi = | PMID = 2051659 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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*[[Rosai-Dorfman disease]] - histiocyte nuclei large (~2-3x lymphocyte) and round with a prominent nucleolus. | *[[Rosai-Dorfman disease]] - histiocyte nuclei large (~2-3x lymphocyte) and round with a prominent nucleolus. | ||
*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment. | *[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment. | ||
*[[Lymph node metastasis]] - usually not difficult if one compares with the | *[[Lymph node metastasis]] - usually not difficult if one compares with the germinal center macrophages and the primary tumour. | ||
===Images=== | ===Images=== | ||
| Line 26: | Line 30: | ||
Image: Sinus histiocytosis - deep -- high mag.jpg | SH - high mag. | Image: Sinus histiocytosis - deep -- high mag.jpg | SH - high mag. | ||
</gallery> | </gallery> | ||
==IHC== | |||
*CD68 +ve. | |||
*S-100 -ve. | |||
==Sign out== | ==Sign out== | ||
| Line 35: | Line 43: | ||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lymph node pathology]] | [[Category:Lymph node pathology]] | ||
Revision as of 15:49, 1 December 2013
Sinus histiocytosis, abbreviated SH, is a common finding in lymph nodes.
It should not be confused with Rosai-Dorfman disease (also known as sinus histiocytosis and massive lymphadenopathy).
General
- Benign.
- Non-specific finding.
- Frequently associated with infections and neoplasia.[1]
- Reported in association with hip replacements.[2]
Gross
- +/-Enlargement of lymph node.[3]
Microscopic
Features:[4]
- Sinuses distended with histiocytes - key feature.
- Histocytes: abundant foamy cytoplasm, +/-anthrocotic pigment.
- Plasma cells increased.
DDx:
- Rosai-Dorfman disease - histiocyte nuclei large (~2-3x lymphocyte) and round with a prominent nucleolus.
- Dermatopathic lymphadenopathy - histiocytes have (melanin) pigment.
- Lymph node metastasis - usually not difficult if one compares with the germinal center macrophages and the primary tumour.
Images
SH - intermed. mag.
SH - high mag.
SH - high mag.
IHC
- CD68 +ve.
- S-100 -ve.
Sign out
- The finding is often ignored; may be signed out as morphologically benign lymph nodes.
See also
References
- ↑ Hartmann, S.; Kriener, S.; Hansmann, ML. (Jul 2008). "[Diagnostic spectrum of reactive lymph node changes].". Pathologe 29 (4): 253-63. doi:10.1007/s00292-008-1003-5. PMID 18504582.
- ↑ Albores-Saavedra, J.; Vuitch, F.; Delgado, R.; Wiley, E.; Hagler, H. (Jan 1994). "Sinus histiocytosis of pelvic lymph nodes after hip replacement. A histiocytic proliferation induced by cobalt-chromium and titanium.". Am J Surg Pathol 18 (1): 83-90. PMID 8279630.
- ↑ Saito, T.; Kuwahara, A.; Kaketani, K.; Hirao, E.; Miyahara, M.; Shimoda, K.; Kobayashi, M. (Mar 1991). "Preoperative assessment of cervical lymph node involvement in esophageal cancer.". Jpn J Surg 21 (2): 145-53. PMID 2051659.
- ↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 179. ISBN 978-0781775960.