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Difference between revisions of "Sinonasal undifferentiated carcinoma"
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Sinonasal undifferentiated carcinoma (view source)
Revision as of 18:07, 20 December 2023
, 18:07, 20 December 2023SMARC4
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| Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition | | Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], others | | LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], [[SMARCA4-deficient sinonasal carcinoma]], [[nasopharyngeal carcinoma]], others | ||
| Stains = | | Stains = | ||
| IHC = pankeratin +ve, [[EMA]] +ve, [[CK7]] +ve, [[CK5/6]] -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, [[p63]] +ve/-ve | | IHC = pankeratin +ve, [[EMA]] +ve, [[CK7]] +ve, [[CK5/6]] -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, [[p63]] +ve/-ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = [[EBER]] -ve | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Line 52: | Line 52: | ||
*[[Small cell carcinoma]]. | *[[Small cell carcinoma]]. | ||
*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Antonescu | first2 = CR. | last3 = Westra | first3 = WH. | title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 38 | issue = 9 | pages = 1282-9 | month = Sep | year = 2014 | doi = 10.1097/PAS.0000000000000285 | PMID = 25007146 }}</ref> | *[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Antonescu | first2 = CR. | last3 = Westra | first3 = WH. | title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 38 | issue = 9 | pages = 1282-9 | month = Sep | year = 2014 | doi = 10.1097/PAS.0000000000000285 | PMID = 25007146 }}</ref> | ||
*[[SMARCA4-deficient sinonasal carcinoma]].<ref name=pmid34871352>{{cite journal |authors=Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D |title=SMARCA4/BRG1-Deficient Sinonasal Carcinoma |journal=Arch Pathol Lab Med |volume=146 |issue=9 |pages=1122–1130 |date=September 2022 |pmid=34871352 |doi=10.5858/arpa.2021-0001-OA |url=}}</ref> | |||
*[[Nasopharyngeal carcinoma]]. | |||
*Other tumours, especially [[small round blue cell tumours]] and [[lymphoma]]. | *Other tumours, especially [[small round blue cell tumours]] and [[lymphoma]]. | ||
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**Nuclear staining lost in [[SMARCB1-deficient sinonasal carcinoma]]. | **Nuclear staining lost in [[SMARCB1-deficient sinonasal carcinoma]]. | ||
===Comparison between different | ===Comparison between different sinonasal carcinomas=== | ||
Based on a modest size study, keratins can useful for subclassifying sinonasal carcinomas:<ref name=pmid12459626>{{cite journal |authors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M |title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns |journal=Am J Surg Pathol |volume=26 |issue=12 |pages=1597–604 |date=December 2002 |pmid=12459626 |doi=10.1097/00000478-200212000-00007 |url=}}</ref> | |||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
! Diagnosis | ! Diagnosis | ||
| Line 92: | Line 94: | ||
|- | |- | ||
| Sinonasal undifferentiated carcinoma (SNUC) | | Sinonasal undifferentiated carcinoma (SNUC) | ||
| 0% | | +0% | ||
| 0% | | +0% | ||
| 50% | | +50% | ||
| 0% | | +0% | ||
| 0% | | +0% | ||
| 50% | | +50% | ||
|- | |- | ||
| Nasopharyngeal-type undifferentiated carcinoma (NPTC) | | Nasopharyngeal-type undifferentiated carcinoma (NPTC) | ||
| 0% | | +0% | ||
| 80% | | +80% | ||
| 0% | | +0% | ||
| 80% | | +80% | ||
| 0% | | +0% | ||
| 100% | | +100% | ||
|- | |- | ||
| Nonkeratinizing squamous cell carcinoma (NKSCC) | | Nonkeratinizing squamous cell carcinoma (NKSCC) | ||
| 0% | | +0% | ||
| 90% | | +90% | ||
| 0% | | +0% | ||
| 80% | | +80% | ||
| 80% | | +80% | ||
| 90% | | +90% | ||
|- | |- | ||
|Squamous cell carcinoma | |Squamous cell carcinoma (keratainizing) | ||
| 30% | | +30% | ||
| 90% | | +90% | ||
| 60% | | +60% | ||
| 90% | | +90% | ||
| 80% | | +80% | ||
| 90% | | +90% | ||
|- | |- | ||
|} | |} | ||
==Molecular== | |||
*EBER -ve.<ref name=pmid11176064>{{cite journal |authors=Cerilli LA, Holst VA, Brandwein MS, Stoler MH, Mills SE |title=Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association |journal=Am J Surg Pathol |volume=25 |issue=2 |pages=156–63 |date=February 2001 |pmid=11176064 |doi=10.1097/00000478-200102000-00003 |url=}}</ref> | |||
==See also== | ==See also== | ||