Difference between revisions of "Sinonasal undifferentiated carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sinonasal_undifferentiated_carcinoma_-_high_mag.jpg | |||
| Width = | |||
| Caption = SNUC. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition | |||
| Subtypes = | |||
| LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], others | |||
| Stains = | |||
| IHC = pankeratin +ve, [[EMA]] +ve, CK7 +ve, CK5/6 -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, p63 +ve/-ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[head and neck pathology|head and neck]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = other head and neck tumours | |||
| Tx = | |||
}} | |||
'''Sinonasal undifferentiated carcinoma''', abbreviated '''SNUC''', is a rare epithelial malignancy of the [[head and neck pathology|head and neck]]. | '''Sinonasal undifferentiated carcinoma''', abbreviated '''SNUC''', is a rare epithelial malignancy of the [[head and neck pathology|head and neck]]. | ||
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*Glandular and squamous differentiation are absent by definition.<ref name=pmid11904342/> | *Glandular and squamous differentiation are absent by definition.<ref name=pmid11904342/> | ||
DDx: | |||
*www: | *Poorly differentiated [[squamous cell carcinoma of the head and neck]]. | ||
*[[Small cell carcinoma]]. | |||
*Other tumours. | |||
===Images=== | |||
www: | |||
*[http://www.nature.com/modpathol/journal/v15/n3/fig_tab/3880522f7.html SNUC (nature.com)].<ref name=pmid11904342>{{Cite journal | last1 = Mills | first1 = SE. | title = Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. | journal = Mod Pathol | volume = 15 | issue = 3 | pages = 264-78 | month = Mar | year = 2002 | doi = 10.1038/modpathol.3880522 | PMID = 11904342 | URL = http://dx.doi.org/10.1038/modpathol.3880522 }}</ref> | |||
*[http://www.pathologypics.com/PictView.aspx?ID=244 SNUC (pathologypics.com)]. | |||
*[http://www.pathologypics.com/PictView.aspx?ID=249 SNUC (pathologypics.com)]. | |||
<gallery> | |||
Image:Sinonasal_undifferentiated_carcinoma_-_low_mag.jpg | SNUC - low mag. (WC) | |||
Image:Sinonasal_undifferentiated_carcinoma_-_high_mag.jpg | SNUC - high mag. (WC) | |||
Image:Sinonasal_undifferentiated_carcinoma_-_very_high_mag.jpg | SNUC - very high mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Revision as of 07:00, 27 July 2014
| Sinonasal undifferentiated carcinoma | |
|---|---|
| Diagnosis in short | |
 SNUC. H&E stain. | |
|
| |
| LM | tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition |
| LM DDx | poorly differentiated squamous cell carcinoma of the head and neck, small cell carcinoma, others |
| IHC | pankeratin +ve, EMA +ve, CK7 +ve, CK5/6 -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, p63 +ve/-ve |
| Site | head and neck |
|
| |
| Prevalence | rare |
| Prognosis | poor |
| Clin. DDx | other head and neck tumours |
Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare epithelial malignancy of the head and neck.
General
- Aggressive/poor prognosis.
Microscopic
Features:[3]
- Architecture: nested, trabecular or lobular.
- Distinct cellular borders.
- Small-to-moderate cytoplasm.
- +/-Distinct nucleoli.
- Tumour cell size variable (small to large).
Note:
- Glandular and squamous differentiation are absent by definition.[4]
DDx:
- Poorly differentiated squamous cell carcinoma of the head and neck.
- Small cell carcinoma.
- Other tumours.
Images
www:
SNUC - low mag. (WC)
SNUC - high mag. (WC)
SNUC - very high mag. (WC)
IHC
Features:[3]
- Pankeratin +ve.
- EMA +ve.
- CK7 +ve.
- CK5/6 -ve.
Others:
- NSE +ve/-ve.
- Chromogranin A -ve.
- Synaptophysin -ve.
- p63 +ve/-ve.[5]
See also
References
- ↑ Pitman, KT.; Costantino, PD.; Lassen, LF. (1995). "Sinonasal undifferentiated carcinoma: current trends in treatment.". Skull Base Surg 5 (4): 269-72. PMC 1656535. PMID 17170968. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1656535/.
- ↑ Al-Mamgani, A.; van Rooij, P.; Mehilal, R.; Tans, L.; Levendag, PC. (Apr 2012). "Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature.". Eur Arch Otorhinolaryngol. doi:10.1007/s00405-012-2008-5. PMID 22476411.
- ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 38. ISBN 978-0781765275.
- ↑ 4.0 4.1 Mills, SE. (Mar 2002). "Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas.". Mod Pathol 15 (3): 264-78. doi:10.1038/modpathol.3880522. PMID 11904342.
- ↑ Wadsworth, B.; Bumpous, JM.; Martin, AW.; Nowacki, MR.; Jenson, AB.; Farghaly, H. (Dec 2011). "Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV).". Head Neck Pathol 5 (4): 349-54. doi:10.1007/s12105-011-0285-8. PMC 3210220. PMID 21805120. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210220/.