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Difference between revisions of "Sertoli-Leydig cell tumour"
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→Microscopic
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*****Lumen is round. | *****Lumen is round. | ||
***Mitotic activity may be much lower than expected for the degree of atypia (in comparison to adenocarcinoma). | ***Mitotic activity may be much lower than expected for the degree of atypia (in comparison to adenocarcinoma). | ||
**Stroma | |||
***Varies from fibrous pink stroma in well differentiated tumors to cellular primative stroma in poorly differentiated tumors. | |||
***+/-Stromal edema may be prominent | |||
*Growth Patterns: | *Growth Patterns: | ||
**Well-differentiated. | **Well-differentiated. | ||
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***Tubules may be a very minor element. | ***Tubules may be a very minor element. | ||
***Poorly differentiated tumours have sarcomatous features.<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | ***Poorly differentiated tumours have sarcomatous features.<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | ||
**Retiform.<ref>{{Cite journal | last1 = Young | first1 = RH. | last2 = Scully | first2 = RE. | title = Ovarian Sertoli-Leydig cell tumors with a retiform pattern: a problem in histopathologic diagnosis. A report of 25 cases. | journal = Am J Surg Pathol | volume = 7 | issue = 8 | pages = 755-71 | month = Dec | year = 1983 | doi = | PMID = 6660351 }}</ref> | |||
***Tumour resembles rete testis/ovary with an irregular network of elongated slit-like tubules and cysts, which may contain papillae. | |||
**With heterologous element. | **With heterologous element. | ||
***Mucinous intestinal-type epithelium, cartilage, skeletal muscle. | ***Mucinous intestinal-type epithelium, cartilage, skeletal muscle. | ||
***Heterologous elements can | ***Heterologous elements can occur in retiform or poorly differentiated tumours. | ||
** | ***+/-Sarcomatous features (mucinous glands, bone, cartilage). | ||
*+/-Sarcomatous features (mucinous glands, bone, cartilage). | |||
DDx: | DDx: | ||