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Serrated polyposis syndrome (view source)
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''' | [[Image:Hyperplastic polyp -- high mag.jpg|thumb|right|150px|Micrograph showing the serrations of a [[hyperplastic polyp]] as may be seen in serrated polyposis syndrome.]] | ||
'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of serrated (colonic) polyps ([[hyperplastic polyp]]s, [[sessile serrated adenoma]]s), probably represents several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal | last1 = Huang | first1 = CS. | last2 = Farraye | first2 = FA. | last3 = Yang | first3 = S. | last4 = O'Brien | first4 = MJ. | title = The clinical significance of serrated polyps. | journal = Am J Gastroenterol | volume = 106 | issue = 2 | pages = 229-40; quiz 241 | month = Feb | year = 2011 | doi = 10.1038/ajg.2010.429 | PMID = 21045813 | URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref> | |||
No specific gene mutation for the syndrome is identified as of 2012.<ref name=pmid22710576>{{Cite journal | last1 = Rex | first1 = DK. | last2 = Ahnen | first2 = DJ. | last3 = Baron | first3 = JA. | last4 = Batts | first4 = KP. | last5 = Burke | first5 = CA. | last6 = Burt | first6 = RW. | last7 = Goldblum | first7 = JR. | last8 = Guillem | first8 = JG. | last9 = Kahi | first9 = CJ. | title = Serrated lesions of the colorectum: review and recommendations from an expert panel. | journal = Am J Gastroenterol | volume = 107 | issue = 9 | pages = 1315-29; quiz 1314, 1330 | month = Sep | year = 2012 | doi = 10.1038/ajg.2012.161 | PMID = 22710576 }}</ref> | |||
==WHO definition== | ==WHO definition== | ||
One of the following three:<ref name= | One of the following three:<ref name=pmid22710576/><ref name=pmid21660283>{{Cite journal | last1 = Rosty | first1 = C. | last2 = Parry | first2 = S. | last3 = Young | first3 = JP. | title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. | journal = Patholog Res Int | volume = 2011 | issue = | pages = 157073 | month = | year = 2011 | doi = 10.4061/2011/157073 | PMID = 21660283 | URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref> | ||
#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm. | #>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm. | ||
#One [[hyperplastic polyp]] | #One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome. | ||
#> | #>20 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps. | ||
==See also== | |||
*[[MUTYH polyposis syndrome]]. | |||
==References== | ==References== | ||
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[[Category:Syndromes]] | [[Category:Syndromes]] | ||
[[Category:Gastrointestinal pathology]] | |||