Difference between revisions of "Serrated polyposis syndrome"
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''' | '''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of (colonic) [[hyperplastic polyp]]s, may represent several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal | last1 = Huang | first1 = CS. | last2 = Farraye | first2 = FA. | last3 = Yang | first3 = S. | last4 = O'Brien | first4 = MJ. | title = The clinical significance of serrated polyps. | journal = Am J Gastroenterol | volume = 106 | issue = 2 | pages = 229-40; quiz 241 | month = Feb | year = 2011 | doi = 10.1038/ajg.2010.429 | PMID = 21045813 | URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref> | ||
==WHO definition== | ==WHO definition== | ||
One of the following three:<ref name= | One of the following three:<ref name=pmid21660283>{{Cite journal | last1 = Rosty | first1 = C. | last2 = Parry | first2 = S. | last3 = Young | first3 = JP. | title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. | journal = Patholog Res Int | volume = 2011 | issue = | pages = 157073 | month = | year = 2011 | doi = 10.4061/2011/157073 | PMID = 21660283 | URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref> | ||
#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm. | #>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm. | ||
#One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome. | #One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome. | ||
#> | #>20 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps. | ||
#*One source<ref name= | #*One source suggests it ought to be >=30 HPs.<ref name=pmid21045813>{{Cite journal | last1 = Huang | first1 = CS. | last2 = Farraye | first2 = FA. | last3 = Yang | first3 = S. | last4 = O'Brien | first4 = MJ. | title = The clinical significance of serrated polyps. | journal = Am J Gastroenterol | volume = 106 | issue = 2 | pages = 229-40; quiz 241 | month = Feb | year = 2011 | doi = 10.1038/ajg.2010.429 | PMID = 21045813 | URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref> | ||
==See also== | ==See also== | ||
Revision as of 22:23, 19 January 2012
Serrated polyposis syndrome, previously known as hyperplastic polyposis syndrome, is an uncommon condition characterized by the presence of (colonic) hyperplastic polyps, may represent several distinct pathologies and is associated with an increased risk of colorectal carcinoma.[1]
WHO definition
One of the following three:[2]
- >=Five hyperplastic polyps proximal to the sigmoid colon with two of the five >=10 mm.
- One hyperplastic polyp proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.
- >20 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
- One source suggests it ought to be >=30 HPs.[1]
See also
References
- ↑ 1.0 1.1 Huang, CS.; Farraye, FA.; Yang, S.; O'Brien, MJ. (Feb 2011). "The clinical significance of serrated polyps.". Am J Gastroenterol 106 (2): 229-40; quiz 241. doi:10.1038/ajg.2010.429. PMID 21045813.
- ↑ Rosty, C.; Parry, S.; Young, JP. (2011). "Serrated polyposis: an enigmatic model of colorectal cancer predisposition.". Patholog Res Int 2011: 157073. doi:10.4061/2011/157073. PMID 21660283.