Difference between revisions of "Serous tubal intraepithelial carcinoma"

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Serous tubal intraepithelial carcinoma (view source)

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Serous tubal intraepithelial carcinoma -- low mag.jpg
| Width      =
| Caption    = Micrograph showing serous tubal intraepithelial carcinoma. [[H&E stain]].
| Synonyms  =
| Micro      = three of the following five: (1) atypical chromatin pattern, (2) nuclear enlargement, (3) nuclear pleomorphism, (4) nuclear moulding, (5) loss of nuclear polarity ''or'' epithelial stratification
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        = p16 +ve, p53 +ve, Ki-67 increased
| EM        =
| Molecular  = BRCA1 mutation or BRCA2 mutation
| IF        =
| Gross      = not apparent on gross
| Grossing  =
| Staging    =
| Site      = [[fallopian tubes]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  = none
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]].
'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]].


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==General==
==General==
*Considered the precursor lesion for tubal [[serous carcinoma]].<ref name=pmid17117391>{{Cite journal  | last1 = Lee | first1 = Y. | last2 = Miron | first2 = A. | last3 = Drapkin | first3 = R. | last4 = Nucci | first4 = MR. | last5 = Medeiros | first5 = F. | last6 = Saleemuddin | first6 = A. | last7 = Garber | first7 = J. | last8 = Birch | first8 = C. | last9 = Mou | first9 = H. | title = A candidate precursor to serous carcinoma that originates in the distal fallopian tube. | journal = J Pathol | volume = 211 | issue = 1 | pages = 26-35 | month = Jan | year = 2007 | doi = 10.1002/path.2091 | PMID = 17117391 }}</ref>
*Considered the precursor lesion for tubal [[serous carcinoma]].<ref name=pmid17117391>{{Cite journal  | last1 = Lee | first1 = Y. | last2 = Miron | first2 = A. | last3 = Drapkin | first3 = R. | last4 = Nucci | first4 = MR. | last5 = Medeiros | first5 = F. | last6 = Saleemuddin | first6 = A. | last7 = Garber | first7 = J. | last8 = Birch | first8 = C. | last9 = Mou | first9 = H. | title = A candidate precursor to serous carcinoma that originates in the distal fallopian tube. | journal = J Pathol | volume = 211 | issue = 1 | pages = 26-35 | month = Jan | year = 2007 | doi = 10.1002/path.2091 | PMID = 17117391 }}</ref>
*Seen in ~6% of prophylactic salpingo-oophorectomies in [[BRCA]]-mutation carriers.<ref name=pmid22710074>{{cite journal |author=Mingels MJ, Roelofsen T, van der Laak JA, ''et al.'' |title=Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls |journal=Gynecol. Oncol. |volume=127 |issue=1 |pages=88–93 |year=2012 |month=October |pmid=22710074 |doi=10.1016/j.ygyno.2012.06.015 |url=}}</ref>


==Gross==
==Gross==
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*#Nuclear moulding.
*#Nuclear moulding.
*#Loss of nuclear polarity ''or'' epithelial stratification.
*#Loss of nuclear polarity ''or'' epithelial stratification.
Notes:
*At low power STIC is usually tall cells that are too blue.
*Cilia suggest benign.
DDx:
*Atypical tubal lesion (STIL or ''tubal intraepithelial lesions in transition'' (TILT)<ref>{{cite journal |authors=Nishida N, Murakami F, Higaki K |title=Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer |journal=Pathol Int |volume=66 |issue=6 |pages=337–42 |date=June 2016 |pmid=27250113 |doi=10.1111/pin.12419 |url=}}</ref>) - lack proliferation.{{fact}}


===Images===
===Images===
<gallery>
Image: Serous tubal intraepithelial carcinoma -- extremely low mag.jpg | STIC - extremely low mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- very low mag.jpg | STIC - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- low mag.jpg | STIC - low mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- intermed mag.jpg | STIC - intermed. mag. (WC)
Image: Serous tubal intraepithelial carcinoma - alt -- intermed mag.jpg | STIC - intermed. mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- high mag.jpg | STIC - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma - alt -- high mag.jpg | STIC - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- very high mag.jpg | STIC - very high mag. (WC)
</gallery>
====www====
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal  | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref>
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal  | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal  | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal  | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref>
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Features:<ref name=pmid21989347/>
Features:<ref name=pmid21989347/>
*p53 +ve.
*p53 +ve.
*Ki-67 +ve.
*Ki-67 increased ~10%. (???)
*p16 +ve.<ref name=pmid20228782/>
*p16 +ve.<ref name=pmid20228782/>
===Images===
<gallery>
Image: Serous tubal intraepithelial carcinoma - p16 -- very low mag.jpg | STIC - p16 - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- low mag.jpg | STIC - p16 - low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- intermed mag.jpg | STIC - p16 - intermed. mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- high mag.jpg | STIC - p16 - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p53 -- very low mag.jpg | STIC - p53 - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p53 -- low mag.jpg | STIC - p53 - low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p53 -- intermed mag.jpg | STIC - p53 - intermed. mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p53 -- high mag.jpg | STIC - p53 - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma - Ki-67 -- very low mag.jpg | STIC - Ki-67 - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - Ki-67  -- low mag.jpg | STIC - Ki-67 - low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - Ki-67  -- high mag.jpg | STIC - Ki-67 - high mag. (WC)
</gallery>


==See also==
==See also==
Michael
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