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Difference between revisions of "Serous carcinoma of the ovary"
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Serous carcinoma of the ovary (view source)
Revision as of 23:37, 1 January 2014
, 23:37, 1 January 2014→Grading
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| Low-grade (Type I) | | Low-grade (Type I) | ||
| mild/moderate atypia: round/oval nuclei, evenly distributed <br>chromatin, +/-conspicuous nucleoli | | mild/moderate atypia: round/oval nuclei, evenly distributed <br>chromatin, +/-conspicuous nucleoli | ||
| <=12 mitoses/ | | <=12 mitoses/10 HPFs † | ||
|- | |- | ||
| High-grade (Type II) | | High-grade (Type II) | ||
| severe atypia: >=3:1 size variation, irregular <br>chromatin, +/-[[macronucleoli]] | | severe atypia: >=3:1 size variation, irregular <br>chromatin, +/-[[macronucleoli]] | ||
| >12 mitoses/ | | >12 mitoses/10 HPFs † | ||
|} | |} | ||
Notes: | Notes: | ||
* † Definition suffers from [[HPFitis]]. | * † Definition suffers from [[HPFitis]]. | ||
** In fairness, the paper<ref name=pmid15087669/> notes that the ''Olympus BH2'' microscope was used. The 40x objective on this microscope has a field diameter of 0.5 mm, according to a manual found online.<ref>URL: [www.alanwood.net/downloads/olympus-bh-2-bht-manual.pdf www.alanwood.net/downloads/olympus-bh-2-bht-manual.pdf]. Accessed on: 1 January 2014.</ref> Assuming this is so, the field area is 0.19635 mm<sup>2</sup>. Thus, in standard units, the cut-point would be 6.1115 mitoses/1 mm<sup>2</sup>. | |||
*Tumours very rarely transform from ''low-grade'' to ''high-grade''.<ref name=pmid22833081>{{Cite journal | last1 = Garg | first1 = K. | last2 = Park | first2 = KJ. | last3 = Soslow | first3 = RA. | title = Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: a report of 3 cases. | journal = Int J Gynecol Pathol | volume = 31 | issue = 5 | pages = 423-8 | month = Sep | year = 2012 | doi = 10.1097/PGP.0b013e31824ae6f2 | PMID = 22833081 }}</ref> | *Tumours very rarely transform from ''low-grade'' to ''high-grade''.<ref name=pmid22833081>{{Cite journal | last1 = Garg | first1 = K. | last2 = Park | first2 = KJ. | last3 = Soslow | first3 = RA. | title = Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: a report of 3 cases. | journal = Int J Gynecol Pathol | volume = 31 | issue = 5 | pages = 423-8 | month = Sep | year = 2012 | doi = 10.1097/PGP.0b013e31824ae6f2 | PMID = 22833081 }}</ref> | ||