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Serous carcinoma of the ovary (view source)
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'''Serous carcinoma of the ovary''', also '''ovarian serous carcinoma''', is relatively common malignant [[ovarian tumour]]. | |||
==General== | |||
*Most common malignant ovarian tumour in the eldery. | |||
*Poor prognosis. | |||
==Microscopic== | |||
Features: | |||
*Marked nuclear pleomorphism: | |||
**Variation in size - usually marked. | |||
**Variation in staining. | |||
**Variation in shape. | |||
*Prominent nucleolus - '''key feature'''. | |||
*Eccentric nucleus. | |||
*Architecture: | |||
**Solid. | |||
**Papillary - classic. | |||
**Glandular - uncommon. | |||
*+/-Psammoma bodies - uncommon. | |||
*+/-Necrosis - often extensive. | |||
DDx: | |||
*[[Clear cell carcinoma of the ovary]] - less nuclear size variation. | |||
*[[Endometrioid carcinoma of the ovary]] - usu. lower grade. | |||
*[[Primary peritoneal serous carcinoma]] - bulk of tumour in peritoneum, small ovarian tumour. | |||
*Other non-ovarian serous carcinomas - ''see [[serous carcinoma]]''. | |||
*[[Ovarian serous borderline tumour]] - mild to moderate nuclear atypia, no invasion, few mitoses. | |||
===Images=== | |||
<gallery> | |||
Image:Serous_carcinoma_cytology.jpg | Serous carcinoma - cytology. (WC) | |||
</gallery> | |||
==IHC== | |||
*WT-1 +ve - '''key immunostain'''.<ref name=pmid18830127>{{Cite journal | last1 = Köbel | first1 = M. | last2 = Kalloger | first2 = SE. | last3 = Carrick | first3 = J. | last4 = Huntsman | first4 = D. | last5 = Asad | first5 = H. | last6 = Oliva | first6 = E. | last7 = Ewanowich | first7 = CA. | last8 = Soslow | first8 = RA. | last9 = Gilks | first9 = CB. | title = A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary. | journal = Am J Surg Pathol | volume = 33 | issue = 1 | pages = 14-21 | month = Jan | year = 2009 | doi = 10.1097/PAS.0b013e3181788546 | PMID = 18830127 }}</ref> | |||
*CK7 +ve. | |||
*CA-125 +ve. | |||
*ER +ve.<ref name=pmid21164285>{{Cite journal | last1 = DeLair | first1 = D. | last2 = Oliva | first2 = E. | last3 = Köbel | first3 = M. | last4 = Macias | first4 = A. | last5 = Gilks | first5 = CB. | last6 = Soslow | first6 = RA. | title = Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases. | journal = Am J Surg Pathol | volume = 35 | issue = 1 | pages = 36-44 | month = Jan | year = 2011 | doi = 10.1097/PAS.0b013e3181ff400e | PMID = 21164285 }}</ref> | |||
*p53 +ve. | |||
Others: | |||
*HNF-1beta -ve.<ref>{{Cite journal | last1 = Tsuchiya | first1 = A. | last2 = Sakamoto | first2 = M. | last3 = Yasuda | first3 = J. | last4 = Chuma | first4 = M. | last5 = Ohta | first5 = T. | last6 = Ohki | first6 = M. | last7 = Yasugi | first7 = T. | last8 = Taketani | first8 = Y. | last9 = Hirohashi | first9 = S. | title = Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. | journal = Am J Pathol | volume = 163 | issue = 6 | pages = 2503-12 | month = Dec | year = 2003 | doi = | PMID = 14633622 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed }}</ref><ref name=omim189907>{{OMIM|189907}}</ref> | |||
**Usually +ve in [[clear cell carcinoma of the ovary]]. | |||
==See also== | |||
*[[Ovary]]. | |||
*[[Ovarian tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Ovarian tumours]] | |||