Secretory carcinoma of the salivary gland

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Mammary analogue secretory carcinoma, abbreviated MASC, is a newly described malignant salivary gland tumour.[1]

General

Gross

Microscopic

Features:

  • Large cells with abundant cytoplasm.
  • Small nuclei.
  • +/-Lymphocytic infiltrate.
  • Solid and microcystic growth pattern.

DDx:

Images

Stains

Features:[3]

IHC

Features:[3]

  • S-100 +ve.[1]
  • Mammomglobin +ve.
  • Vimentin +ve.

Molecular

  • t(12;15)(p13;q25).
    • Fusion of the genes ETV6 and NTRK3.[1]

Note:

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.
  3. 3.0 3.1 3.2 3.3 Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.