Difference between revisions of "Secretory carcinoma of the salivary gland"

Jump to navigation Jump to search

Secretory carcinoma of the salivary gland (view source)

Revision as of 20:53, 2 November 2021

1,690 bytes added ,  20:53, 2 November 2021
→‎Sign out
 
(14 intermediate revisions by the same user not shown)
Line 3: Line 3:
| Image      = Mammary analogue secretory carcinoma (H&E, medium power).jpg
| Image      = Mammary analogue secretory carcinoma (H&E, medium power).jpg
| Width      =
| Width      =
| Caption    = Mammary analogue secretory carcinoma. [[H&E stain]]. (WC/NormanDy)
| Caption    = Secretory carcinoma of the salivary gland. [[H&E stain]]. (WC/NormanDy)
| Synonyms  =
| Synonyms  = Mammary analogue secretory carcinoma (previous name)
| Micro      = large cells with abundant cytoplasm, small nuclei, +/-lymphocytic infiltrate, solid and microcystic growth pattern
| Micro      = large cells with abundant cytoplasm, small nuclei, +/-lymphocytic infiltrate, solid and microcystic growth pattern
| Subtypes  =
| Subtypes  =
| LMDDx      = [[acinic cell carcinoma]], [[mucoepidermoid carcinoma]]
| LMDDx      = [[acinic cell carcinoma]], [[mucoepidermoid carcinoma]]
| Stains    = [[PAS stain|PAS]] +ve
| Stains    = [[PAS stain|PAS]] +ve
| IHC        = S-100 +ve, mammomglobin +ve, vimentin +ve
| IHC        = S-100 +ve, mammaglobin +ve, vimentin +ve
| EM        =
| EM        =
| Molecular  = ETV6-NTRK3 fusion gene
| Molecular  = ETV6-[[NTRK3]] fusion gene
| IF        =
| IF        =
| Gross      =
| Gross      =
Line 28: Line 28:
| Other      =
| Other      =
| ClinDDx    = other [[salivary gland]] tumours
| ClinDDx    = other [[salivary gland]] tumours
| Tx        =
| Tx        = excision
}}
}}
'''Mammary analogue secretory carcinoma''', abbreviated '''MASC''', is a newly described [[malignant]] [[salivary gland]] tumour.<ref name=pmid22127547>{{Cite journal  | last1 = Lei | first1 = Y. | last2 = Chiosea | first2 = SI. | title = Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. | journal = Head Neck Pathol | volume = 6 | issue = 2 | pages = 166-70 | month = Jun | year = 2012 | doi = 10.1007/s12105-011-0312-9 | PMID = 22127547 }}</ref>
'''Secretory carcinoma of the salivary gland''' is an uncommon [[malignant]] [[salivary gland]] tumour that was first described in 2010.<ref name=pmid22127547>{{Cite journal  | last1 = Lei | first1 = Y. | last2 = Chiosea | first2 = SI. | title = Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. | journal = Head Neck Pathol | volume = 6 | issue = 2 | pages = 166-70 | month = Jun | year = 2012 | doi = 10.1007/s12105-011-0312-9 | PMID = 22127547 }}</ref>
 
It was previously known as '''mammary analogue secretory carcinoma''', abbreviated '''MASC'''.<ref name=pmid31007960>{{cite journal |authors=Montalvo N, Galarza D, Redrobán L |title=Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available |journal=Case Rep Pathol |volume=2019 |issue= |pages=5103496 |date=2019 |pmid=31007960 |pmc=6441535 |doi=10.1155/2019/5103496 |url=}}</ref>


==General==
==General==
Line 56: Line 58:


===Images===
===Images===
====Case 1====
<gallery>
<gallery>
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_low_power).jpg | MASC - low. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_low_power).jpg | SC - low. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_medium_power).jpg | MASC - med. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_medium_power).jpg | SC - med. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_high_power).jpg | MASC - high. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_high_power).jpg | SC - high. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_high_power),_solid.jpg | MAS - high solid. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(H%26E,_high_power),_solid.jpg | SC - high solid. (WC/NormanDy)
</gallery>
</gallery>
www:
====Case 2====
<gallery>
Image: Secretory carcinoma of salivary gland -- low mag.jpg | SCSG - low mag. (WC)
Image: Secretory carcinoma of salivary gland -- intermed mag.jpg | SCSG - intermed. mag. (WC)
Image: Secretory carcinoma of salivary gland -- high mag.jpg | SCSG - high mag. (WC)
Image: Secretory carcinoma of salivary gland - alt -- high mag.jpg | SCSG - high mag. (WC)
</gallery>
 
====www====
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig1/ AcCC - the main DDx of MASC (nih.gov)].<ref name=pmid22127547/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig1/ AcCC - the main DDx of MASC (nih.gov)].<ref name=pmid22127547/>
Line 75: Line 86:
==IHC==
==IHC==
Features:<ref name=pmid20410810/>
Features:<ref name=pmid20410810/>
*S-100 +ve.<ref name=pmid22127547/>
*[[S-100]] +ve.<ref name=pmid22127547/>
*Mammomglobin +ve.
*Mammaglobin +ve.
*Vimentin +ve.
*Vimentin +ve.


Others:
Others:
*p63 -ve.
*[[p63]] -ve.
**Unusual in mucoepidermoid carcinoma.
**Unusual in mucoepidermoid carcinoma.
*HMWCK -ve.
*HMWCK -ve.
*GATA3 +ve.
*[[GATA3]] +ve.


Panel:
Panel:
*S-100, mammoglobin, p63, HMWCK.
*S-100, mammaglobin, p63, HMWCK.


===Images===
===Images===
<gallery>
<gallery>
Image:Mammary_analogue_secretory_carcinoma_(mammaglobin_immunohistochemstry,_medium_power).jpg | MASC - mammaglobulin. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(mammaglobin_immunohistochemstry,_medium_power).jpg | MASC - mammaglobin. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(S100immunohistochemstry,_low_power).jpg | MASC - S-100. (WC/NormanDy)
Image:Mammary_analogue_secretory_carcinoma_(S100immunohistochemstry,_low_power).jpg | MASC - S-100. (WC/NormanDy)
</gallery>
</gallery>
Line 96: Line 107:
==Molecular==
==Molecular==
*t(12;15)(p13;q25).  
*t(12;15)(p13;q25).  
**Fusion of the genes ''ETV6'' and ''NTRK3''.<ref name=pmid22127547/>
**Fusion of the genes ''ETV6'' and ''[[NTRK3]]''.<ref name=pmid22127547/>


Note:
Note:
*The translocation seen in [[secretory breast carcinoma]], [[congenital-infantile fibrosarcoma]] and [[mesoblastic nephroma]].
*The translocation seen in [[secretory breast carcinoma]], [[congenital-infantile fibrosarcoma]] and [[mesoblastic nephroma]].
==Sign out==
<pre>
Right Parotid Lesion, Core Biopsy:
    - SECRETORY CARCINOMA of the salivary gland, see comment.
Comment:
Secretory carcinoma of the salivary gland was previously known as "mammary analogue secretory carcinoma" (MASC).
The tumour stains as follows:
POSITIVE: CK7 (strong, diffuse), mammaglobin (strong, diffuse), S100 (moderate, patchy), mucin (focal).
NEGATIVE: p63.
NTRK testing was ordered; the results will be reported in an addendum.
</pre>
===Micro===
The sections show a cohesive tumor with moderate amphophilic cytoplasm and vacuolation. The vacuolation is focally prominent. Nucleoli are inconspicuous. Poorly formed glands are present. Keratinization is absent.


==See also==
==See also==
*[[Salivary gland]].
*[[Salivary gland]].
*[[Secretory breast carcinoma]].
*[[Secretory breast carcinoma]].
*[[Secretory carcinoma]].


==References==
==References==
Michael
48,454

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/43044...51594"

Navigation menu