Difference between revisions of "Secretory carcinoma of the salivary gland"

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==General==
==General==
*Microscopic appearance similar to [[secretory breast carcinoma]].<ref name=pmid20410810>{{Cite journal  | last1 = Skálová | first1 = A. | last2 = Vanecek | first2 = T. | last3 = Sima | first3 = R. | last4 = Laco | first4 = J. | last5 = Weinreb | first5 = I. | last6 = Perez-Ordonez | first6 = B. | last7 = Starek | first7 = I. | last8 = Geierova | first8 = M. | last9 = Simpson | first9 = RH. | title = Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. | journal = Am J Surg Pathol | volume = 34 | issue = 5 | pages = 599-608 | month = May | year = 2010 | doi = 10.1097/PAS.0b013e3181d9efcc | PMID = 20410810 }}</ref>
*Microscopic appearance similar to [[secretory breast carcinoma]].<ref name=pmid20410810>{{Cite journal  | last1 = Skálová | first1 = A. | last2 = Vanecek | first2 = T. | last3 = Sima | first3 = R. | last4 = Laco | first4 = J. | last5 = Weinreb | first5 = I. | last6 = Perez-Ordonez | first6 = B. | last7 = Starek | first7 = I. | last8 = Geierova | first8 = M. | last9 = Simpson | first9 = RH. | title = Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. | journal = Am J Surg Pathol | volume = 34 | issue = 5 | pages = 599-608 | month = May | year = 2010 | doi = 10.1097/PAS.0b013e3181d9efcc | PMID = 20410810 }}</ref>
*Super rare - 21 cases in the world literature as of 2012.<ref name=pmid22127547/>
*Rare - 21 cases in the world literature as of 2012.<ref name=pmid22127547/>
*Original paper described it only in adults.<ref name=pmid20410810/>
*Original paper described it only in adults.<ref name=pmid20410810/>
**Has been described in a pediatric patient.<ref name=pmid21873597>{{Cite journal  | last1 = Rastatter | first1 = JC. | last2 = Jatana | first2 = KR. | last3 = Jennings | first3 = LJ. | last4 = Melin-Aldana | first4 = H. | title = Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. | journal = Otolaryngol Head Neck Surg | volume = 146 | issue = 3 | pages = 514-5 | month = Mar | year = 2012 | doi = 10.1177/0194599811419044 | PMID = 21873597 }}</ref>
**Has been described in a pediatric patient.<ref name=pmid21873597>{{Cite journal  | last1 = Rastatter | first1 = JC. | last2 = Jatana | first2 = KR. | last3 = Jennings | first3 = LJ. | last4 = Melin-Aldana | first4 = H. | title = Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. | journal = Otolaryngol Head Neck Surg | volume = 146 | issue = 3 | pages = 514-5 | month = Mar | year = 2012 | doi = 10.1177/0194599811419044 | PMID = 21873597 }}</ref>

Revision as of 13:00, 6 November 2015

Secretory carcinoma of the salivary gland
Diagnosis in short

Mammary analogue secretory carcinoma. H&E stain. (WC/NormanDy)
LM large cells with abundant cytoplasm, small nuclei, +/-lymphocytic infiltrate, solid and microcystic growth pattern
LM DDx acinic cell carcinoma, mucoepidermoid carcinoma
Stains PAS +ve
IHC S-100 +ve, mammomglobin +ve, vimentin +ve
Molecular ETV6-NTRK3 fusion gene
Site salivary gland - usually parotid
Prevalence rare
Clin. DDx other salivary gland tumours

Mammary analogue secretory carcinoma, abbreviated MASC, is a newly described malignant salivary gland tumour.[1]

General

  • Microscopic appearance similar to secretory breast carcinoma.[2]
  • Rare - 21 cases in the world literature as of 2012.[1]
  • Original paper described it only in adults.[2]
    • Has been described in a pediatric patient.[3]

Gross

Microscopic

Features:

  • Large cells with abundant cytoplasm.
  • Small nuclei.
  • +/-Lymphocytic infiltrate.
  • Solid and microcystic growth pattern.

DDx:

Images

  • MASC - low. (WC/NormanDy)

  • MASC - med. (WC/NormanDy)

  • MASC - high. (WC/NormanDy)

  • MAS - high solid. (WC/NormanDy)

www:

Stains

Features:[2]

IHC

Features:[2]

  • S-100 +ve.[1]
  • Mammomglobin +ve.
  • Vimentin +ve.

Others:

  • p63 -ve.
  • HMWCK -ve.
  • GATA3 +ve.

Panel:

  • S-100, mammoglobin, p63, HMWCK.

Images

  • MASC - mammaglobulin. (WC/NormanDy)

  • MASC - S-100. (WC/NormanDy)

Molecular

  • t(12;15)(p13;q25).
    • Fusion of the genes ETV6 and NTRK3.[1]

Note:

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.
  3. ↑ Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.
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