Difference between revisions of "Secretory carcinoma of the salivary gland"

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===Images===
===Images===
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/>
==IHC==
*S-100 +ve.<ref name=pmid22127547/>


==Molecular==
==Molecular==
*t(12;15)(p13;q25)  
*t(12;15)(p13;q25).
**Fusion of the genes ''ETV6'' and ''NTRK3''.<ref name=pmid22127547/>
**Fusion of the genes ''ETV6'' and ''NTRK3''.<ref name=pmid22127547/>



Revision as of 01:25, 14 February 2014

Mammary analogue secretory carcinoma, abbreviated MASC, is a newly described malignant salivary gland tumour.[1]

General

  • Described in pediatric patient.[2]


Microscopic

Features:

  • Large cells with abundant cytoplasm.
  • Small nuclei.
  • +/-Lymphocytic infiltrate.

DDx:

Images

IHC

Molecular

  • t(12;15)(p13;q25).
    • Fusion of the genes ETV6 and NTRK3.[1]

Note:

See also

References

  1. 1.0 1.1 1.2 1.3 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.