Scleroderma

Scleroderma is a disease that keeps rheumatologists busy.

General

Clinical:

• Anti-centromere antibody (ACA) +ve.
  • Common in limited systemic scleroderma, AKA CREST Syndrome.
• Scl-70 (topoisomerase I) +ve.
  • Common in diffuse scleroderma.

Associated pathology

• Scleroderma panniculitis.

See also

• Basics.
• Systemic lupus erythematosus.