Difference between revisions of "Scleroderma"

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==General==
==General==
Clinical:
Clinical:
*Anti-centromere antibody +ve.
*Anti-centromere antibody (ACA) +ve.
**Common in ''limited systemic scleroderma'', [[AKA]] CREST Syndrome.
**Common in ''limited systemic scleroderma'', [[AKA]] CREST syndrome.
*Scl-70 (topoisomerase I).
*Scl-70 (topoisomerase I) +ve.
**Common in ''diffuse scleroderma''.
**Common in ''diffuse scleroderma''.
CREST syndrome:
*Calcinosis.
*Raynaud's phenomenon.
*[[esophagus|Esophageal]] dysmotility.
*Sclerodactyly.
*Telangiectasia.


==Associated pathology==
==Associated pathology==
*[[Scleroderma panniculitis]].
*[[Scleroderma panniculitis]].
*Scleroderma renal crisis - see ''[[thrombotic microangiopathy]]''.
*Digit ischemia - may require [[finger amputation]].<ref>{{Cite journal  | last1 = Jones | first1 = NF. | last2 = Imbriglia | first2 = JE. | last3 = Steen | first3 = VD. | last4 = Medsger | first4 = TA. | title = Surgery for scleroderma of the hand. | journal = J Hand Surg Am | volume = 12 | issue = 3 | pages = 391-400 | month = May | year = 1987 | doi =  | PMID = 3584887 }}</ref>


==See also==
==See also==
*[[Basics]].
*[[Basics]].
*[[Systemic lupus erythematosus]].
*[[Systemic lupus erythematosus]].
==References==
{{Reflist|1}}


[[Category:Clinical]]
[[Category:Clinical]]
[[Category:Diagnosis]]

Latest revision as of 16:32, 5 August 2015

Scleroderma is a disease that keeps rheumatologists busy.

General

Clinical:

  • Anti-centromere antibody (ACA) +ve.
    • Common in limited systemic scleroderma, AKA CREST syndrome.
  • Scl-70 (topoisomerase I) +ve.
    • Common in diffuse scleroderma.

CREST syndrome:

  • Calcinosis.
  • Raynaud's phenomenon.
  • Esophageal dysmotility.
  • Sclerodactyly.
  • Telangiectasia.

Associated pathology

See also

References

  1. Jones, NF.; Imbriglia, JE.; Steen, VD.; Medsger, TA. (May 1987). "Surgery for scleroderma of the hand.". J Hand Surg Am 12 (3): 391-400. PMID 3584887.