Difference between revisions of "Sarcoma with CIC-rearrangement"

Jump to navigation Jump to search

Sarcoma with CIC-rearrangement (view source)

Revision as of 18:40, 17 February 2022

717 bytes added ,  18:40, 17 February 2022
→‎IHC
 
(7 intermediate revisions by 2 users not shown)
Line 11: Line 11:
| IHC        = WT-1 +ve, CD99 +ve/-ve (not strong membranous), ERG +ve, FLI-1 +ve
| IHC        = WT-1 +ve, CD99 +ve/-ve (not strong membranous), ERG +ve, FLI-1 +ve
| EM        =
| EM        =
| Molecular  = t(4;19)(q35;q13.1) present, EWSR1 abnormality absent
| Molecular  = CIC rearrangement, e.g. t(4;19)(q35;q13.1) present; EWSR1 abnormality absent
| IF        =
| IF        =
| Gross      =
| Gross      =
Line 47: Line 47:
**Irregular spacing of cells.
**Irregular spacing of cells.
**+/-Big nucleoli.
**+/-Big nucleoli.
<gallery>
File:CIC-DUX-sarcoma.jpg | CIC-DUX rearranged sarcoma in the CNS (WC/jensflorian)
</gallery>


DDx:
DDx:
Line 55: Line 59:


===Images===
===Images===
*[http://www.nature.com/modpathol/journal/v28/n1/fig_tab/modpathol201483f1.html CIC-DUX sarcoma - 1 (nature.com)].<ref name=pmid24947144>{{Cite journal  | last1 = Smith | first1 = SC. | last2 = Buehler | first2 = D. | last3 = Choi | first3 = EY. | last4 = McHugh | first4 = JB. | last5 = Rubin | first5 = BP. | last6 = Billings | first6 = SD. | last7 = Balzer | first7 = B. | last8 = Thomas | first8 = DG. | last9 = Lucas | first9 = DR. | title = CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. | journal = Mod Pathol | volume = 28 | issue = 1 | pages = 57-68 | month = Jan | year = 2015 | doi = 10.1038/modpathol.2014.83 | PMID = 24947144 }}</ref>
*[https://www.nature.com/articles/modpathol201483/figures/1 CIC-DUX sarcoma - 1 (nature.com)].<ref name=pmid24947144>{{Cite journal  | last1 = Smith | first1 = SC. | last2 = Buehler | first2 = D. | last3 = Choi | first3 = EY. | last4 = McHugh | first4 = JB. | last5 = Rubin | first5 = BP. | last6 = Billings | first6 = SD. | last7 = Balzer | first7 = B. | last8 = Thomas | first8 = DG. | last9 = Lucas | first9 = DR. | title = CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. | journal = Mod Pathol | volume = 28 | issue = 1 | pages = 57-68 | month = Jan | year = 2015 | doi = 10.1038/modpathol.2014.83 | PMID = 24947144 }}</ref>
*[http://www.nature.com/modpathol/journal/v28/n1/fig_tab/modpathol201483f2.html CIC-DUX sarcoma - 2 (nature.com)].<ref name=pmid24947144/>
*[http://www.nature.com/modpathol/journal/v28/n1/fig_tab/modpathol201483f2.html CIC-DUX sarcoma - 2 (nature.com)].<ref name=pmid24947144/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338805/figure/f2-amjcaserep-16-87/ Sarcoma with t(4;19) (nih.gov)].<ref name=pmid25683183>{{Cite journal  | last1 = Haidar | first1 = A. | last2 = Arekapudi | first2 = S. | last3 = DeMattia | first3 = F. | last4 = Abu-Isa | first4 = E. | last5 = Kraut | first5 = M. | title = High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review. | journal = Am J Case Rep | volume = 16 | issue =  | pages = 87-94 | month =  | year = 2015 | doi = 10.12659/AJCR.892551 | PMID = 25683183 }}</ref>
*[https://www.nature.com/articles/modpathol201483/figures/2 Sarcoma with t(4;19) (nih.gov)].<ref name=pmid25683183>{{Cite journal  | last1 = Haidar | first1 = A. | last2 = Arekapudi | first2 = S. | last3 = DeMattia | first3 = F. | last4 = Abu-Isa | first4 = E. | last5 = Kraut | first5 = M. | title = High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review. | journal = Am J Case Rep | volume = 16 | issue =  | pages = 87-94 | month =  | year = 2015 | doi = 10.12659/AJCR.892551 | PMID = 25683183 }}</ref>


==IHC==
==IHC==
Line 68: Line 72:
*ERG +ve.
*ERG +ve.
*FLI-1 +ve.
*FLI-1 +ve.
*CD56 +ve/-ve (5 +ve of 9<ref name=pmid28197724>{{cite journal |authors=Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y |title=Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes |journal=Virchows Arch |volume=470 |issue=4 |pages=373–380 |date=April 2017 |pmid=28197724 |doi=10.1007/s00428-017-2072-8 |url=}}</ref>).


==Molecular==
==Molecular==
*t(4;19)(q35;q13.1).<ref name=pmid22072439>{{Cite journal  | last1 = Italiano | first1 = A. | last2 = Sung | first2 = YS. | last3 = Zhang | first3 = L. | last4 = Singer | first4 = S. | last5 = Maki | first5 = RG. | last6 = Coindre | first6 = JM. | last7 = Antonescu | first7 = CR. | title = High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. | journal = Genes Chromosomes Cancer | volume = 51 | issue = 3 | pages = 207-18 | month = Mar | year = 2012 | doi = 10.1002/gcc.20945 | PMID = 22072439 }}</ref>
*Rearrangement of CIC gene, e.g. t(4;19)(q35;q13.1); CIC-DUX4 fusion.<ref name=pmid22072439>{{Cite journal  | last1 = Italiano | first1 = A. | last2 = Sung | first2 = YS. | last3 = Zhang | first3 = L. | last4 = Singer | first4 = S. | last5 = Maki | first5 = RG. | last6 = Coindre | first6 = JM. | last7 = Antonescu | first7 = CR. | title = High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. | journal = Genes Chromosomes Cancer | volume = 51 | issue = 3 | pages = 207-18 | month = Mar | year = 2012 | doi = 10.1002/gcc.20945 | PMID = 22072439 }}</ref>
**CIC-DUX4 fusion.
*EWSR1 FISH negative.
*EWSR1 FISH negative.


Michael
48,455

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/49942...51866"

Navigation menu