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Difference between revisions of "Salivary glands"
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+molecular
(+molecular) |
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| '''fuffy, clear,<br>abundant''' | | '''fuffy, clear,<br>abundant''' | ||
| nuclei sm. | | nuclei sm. | ||
| ? | | SCC (?) | ||
| IHC: p63+ | | IHC: p63+ | ||
|- | |- | ||
|Acinic cell adenocarcinoma (AcCC) | |Acinic cell adenocarcinoma (AcCC) | ||
| acinar (islands) | | sheets, acinar (islands) | ||
| epithelioid | | epithelioid | ||
| clear | | clear | ||
| Line 125: | Line 125: | ||
| stippled, +/-occ. nucleoli | | stippled, +/-occ. nucleoli | ||
| ? | | ? | ||
| | | Stains: PAS +ve, PAS-D +ve; [[IHC]]: S-100 -ve, p63 -ve | ||
|- | |- | ||
|Adenoid cystic carcinoma (AdCC) | |Adenoid cystic carcinoma (AdCC) | ||
| Line 133: | Line 133: | ||
| scant,<br>hyperchromatic | | scant,<br>hyperchromatic | ||
| '''small<br>"carrot-shaped"''' | | '''small<br>"carrot-shaped"''' | ||
| | | PLGA | ||
| | | IHC: C-kit+, cyclin D1+ | ||
|- | |- | ||
|Salivary duct carcinoma | |Salivary duct carcinoma | ||
| Line 142: | Line 142: | ||
| hyperchromatic | | hyperchromatic | ||
| columnar | | columnar | ||
| metastatic breast | | metastatic breast carcinoma | ||
| similar to ductal<br>breast carcinoma | | similar to ductal<br>breast carcinoma; male>female | ||
|- | |- | ||
|Polymorphous low-grade adenocarcinoma | |Polymorphous low-grade adenocarcinoma | ||
| Line 151: | Line 151: | ||
| '''eosinophilic''' | | '''eosinophilic''' | ||
| ovoid & small with<br>small nucleoli | | ovoid & small with<br>small nucleoli | ||
| | | AdCC | ||
| minor salivary gland tumour,<br>often in palate,<br> cytologically monotonous; IHC: S100+, CK+, vim.+, GFAP+/-, BCL2+/- | | minor salivary gland tumour,<br>often in palate,<br> cytologically monotonous; IHC: S100+, CK+, vim.+, GFAP+/-, BCL2+/- | ||
|- | |- | ||
| Line 424: | Line 424: | ||
Scoring: | Scoring: | ||
*Low grade | *Low grade = 0-4 points. | ||
*Intermediate grade | *Intermediate grade = 5-6 points. | ||
*High grade | *High grade = 7+ points. | ||
======Weinreb modification====== | |||
Weinreb looks for the following: | |||
*Tumour invades in small nests/islands - 2 points. | |||
**If applicable, the two points are added to the AFIP score. | |||
**The tumour is graded using the AFIP (scoring) cut points -- see above. | |||
===Stains=== | ===Stains=== | ||
| Line 432: | Line 438: | ||
*Alcian blue +ve. | *Alcian blue +ve. | ||
*Mucicarcmine +ve. | *Mucicarcmine +ve. | ||
===Molecular=== | |||
*t(11;19)(q21;p13) -- MECT1-MAML2 fusion.<ref name=pmid12539049>{{cite journal |author=Tonon G, Modi S, Wu L, ''et al.'' |title=t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway |journal=Nat. Genet. |volume=33 |issue=2 |pages=208–13 |year=2003 |month=February |pmid=12539049 |doi=10.1038/ng1083 |url=}}</ref><ref name=pmid20588178>{{cite journal |author=Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN |title=A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas |journal=Am. J. Surg. Pathol. |volume=34 |issue=8 |pages=1106–21 |year=2010 |month=August |pmid=20588178 |doi=10.1097/PAS.0b013e3181de3021 |url=}}</ref> | |||
**Present in ~65% of MECs. | |||
**Presence assoc. with low-grade MEC (vs. high-grade MEC) & favourable prognosis. | |||
**Not seen in tumours that are in the DDx of MEC. | |||
==Acinic cell adenocarcinoma== | ==Acinic cell adenocarcinoma== | ||
| Line 521: | Line 533: | ||
===IHC=== | ===IHC=== | ||
Features:<ref name=pmid19360297>{{Cite journal | last1 = Sequeiros-Santiago | first1 = G. | last2 = García-Carracedo | first2 = D. | last3 = Fresno | first3 = MF. | last4 = Suarez | first4 = C. | last5 = Rodrigo | first5 = JP. | last6 = Gonzalez | first6 = MV. | title = Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. | journal = Oncol Rep | volume = 21 | issue = 5 | pages = 1215-22 | month = May | year = 2009 | doi = | PMID = 19360297 }}</ref> | Features:<ref name=pmid19360297>{{Cite journal | last1 = Sequeiros-Santiago | first1 = G. | last2 = García-Carracedo | first2 = D. | last3 = Fresno | first3 = MF. | last4 = Suarez | first4 = C. | last5 = Rodrigo | first5 = JP. | last6 = Gonzalez | first6 = MV. | title = Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. | journal = Oncol Rep | volume = 21 | issue = 5 | pages = 1215-22 | month = May | year = 2009 | doi = | PMID = 19360297 }}</ref> | ||
*CD117 | *CD117 +ve. | ||
*Cyclin D1 +ve. | *Cyclin D1 +ve. | ||
==Salivary duct carcinoma== | ==Salivary duct carcinoma== | ||