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Difference between revisions of "Salivary glands"
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m
→Adenoid cystic carcinoma
m (→Microscopic) |
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*[http://commons.wikimedia.org/wiki/File:Adenoid_cystic_carcinoma_-a-_very_high_mag.jpg AdCC - very high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Adenoid_cystic_carcinoma_-a-_very_high_mag.jpg AdCC - very high mag. (WC)]. | ||
*[http://www.nature.com/modpathol/journal/v16/n12/fig_tab/3880915f2.html Adenoid cystic carcinoma (nature.com)]. | *[http://www.nature.com/modpathol/journal/v16/n12/fig_tab/3880915f2.html Adenoid cystic carcinoma (nature.com)]. | ||
====Grading==== | ====Grading==== | ||
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*Myoepithelial markers (e.g. calponin, actin) +ve. | *Myoepithelial markers (e.g. calponin, actin) +ve. | ||
**Typically -ve in PLGA. | **Typically -ve in PLGA. | ||
===Molecular=== | |||
Features:<ref>{{Cite journal | last1 = Mitani | first1 = Y. | last2 = Rao | first2 = PH. | last3 = Futreal | first3 = PA. | last4 = Roberts | first4 = D. | last5 = Stephens | first5 = P. | last6 = Zhao | first6 = YJ. | last7 = Zhang | first7 = L. | last8 = Mitani | first8 = M. | last9 = Weber | first9 = RS. | title = Novel Chromosomal Rearrangements and breakpoints at the t(6;9) in Salivary Adenoid Cystic Carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. | journal = Clin Cancer Res | volume = | issue = | pages = | month = Oct | year = 2011 | doi = 10.1158/1078-0432.CCR-11-1870 | PMID = 21976542 }}</ref> | |||
*t(6;9) MYB-NFIB. | |||
**Seen in ~50% of cases. | |||
**Worse prognosis if present, esp. if fusion assoc. with transcription. | |||
==Salivary duct carcinoma== | ==Salivary duct carcinoma== | ||