Difference between revisions of "Salivary glands"

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Salivary glands (view source)

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→‎Polymorphous low-grade adenocarcinoma
 
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| [[basal cell adenoma]]
| [[basal cell adenoma]]
| exclusively oral cavity, 80% in upper lip; IHC: p63-
| exclusively oral cavity, 80% in upper lip; IHC: p63-
| -
| [[Image:Canalicular_adenoma_--_high_mag.jpg | thumb | center |150px| CA. (WC)]]
|-
|-
|[[Sialoblastoma]]
|[[Sialoblastoma]]
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==IHC overview==
==IHC overview==
General:
General:
*Usually has limited value.
*Usually has limited value. <!--as per Ilan Weinreb-->


Specifics:
Overview:
*Luminal markers: [[CK7]], [[CK19]], CAM5.2 (LMWK).
*Luminal markers: [[CK7]], [[CK19]], CAM5.2 (LMWK).
*Basal markers: p63, HMWK, CK14.
*Basal markers: p63, HMWK, CK14.
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Notes:
Notes:
*p63 and S-100 are sometimes call myoepithelial.
*p63 and S-100 are sometimes call myoepithelial.
Specifics:
*Calponin, S-100, Ki-67 may be useful as per Nagao ''et al.''<ref>{{Cite journal  | last1 = Nagao | first1 = T. | last2 = Sato | first2 = E. | last3 = Inoue | first3 = R. | last4 = Oshiro | first4 = H. | last5 = H Takahashi | first5 = R. | last6 = Nagai | first6 = T. | last7 = Yoshida | first7 = M. | last8 = Suzuki | first8 = F. | last9 = Obikane | first9 = H. | title = Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. | journal = Acta Histochem Cytochem | volume = 45 | issue = 5 | pages = 269-82 | month = Oct | year = 2012 | doi = 10.1267/ahc.12019 | PMID = 23209336 }}</ref>


=Benign=
=Benign=
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==Salivary gland mucocele==
==Salivary gland mucocele==
*[[AKA]] ''salivary mucocele''.
{{Main|Salivary gland mucocele}}
*May be referred to as ''[[mucocele]]''.
===General===
*Benign.
*Infected [[mucocele]] = mucopyocele.
 
===Microscopic===
Features:<ref>URL: [http://emedicine.medscape.com/article/1076717-workup http://emedicine.medscape.com/article/1076717-workup]. Accessed on: 6 March 2012.</ref>
*Granulation tissue-like and pseudocyst-like.
**Granulation tissue-like:
***Fibroblasts.
***Small caliber blood vessels.
***Histocytes.
***Neutrophils.
**Pseudocyst:
***No epithelial lining.
***Poorly circumscribed.
*Pale pink extracellular material (mucous) - '''key feature'''.
*+/-[[Granuloma]]s.<ref name=pmid7251405>{{Cite journal  | last1 = Seifert | first1 = G. | last2 = Donath | first2 = K. | last3 = von Gumberz | first3 = C. | title = [Mucoceles of the minor salivary glands. Extravasation mucoceles (mucus granulomas) and retention mucoceles (mucus retention cysts) (author's transl)]. | journal = HNO | volume = 29 | issue = 6 | pages = 179-91 | month = Jun | year = 1981 | doi =  | PMID = 7251405 }}</ref>
 
DDx:
*[[Granulation tissue]].
*[[Signet ring cell carcinoma]] - muciphages may mimic signet ring cells.
 
====Images====
<gallery>
Image:Mucocele_of_lower_lip_%281%29.JPG | Mucocele - low mag. (WC/KGH)
Image:Mucocele_of_lower_lip_%282%29.JPG | Mucocele - high mag. (WC/KGH)
Image:Mucocele_-_low_mag.jpg | Mucocele - low mag. (WC/Nephron)
Image:Mucocele_-_high_mag.jpg | Mucocele - high mag. (WC/Nephron)
</gallery>
www:
*[http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=292590975 Mucocele (dermatlas.med.jhmi.edu)].
 
===Sign out===
<pre>
LESION, LEFT LOWER LIP, EXCISION:
- BENIGN MUCOCELE.
</pre>
 
====Micro====
The sections show a stratified squamous epithelium with a thin layer of parakeratosis,
minor salivary glands, and a well-circumscribed cystic lesion.
 
The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages. No significant nuclear atypia is identified. Mitotic activity is not readily apparent.


==Pleomorphic adenoma==
==Pleomorphic adenoma==
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==Adenoid cystic carcinoma==
==Adenoid cystic carcinoma==
:See: ''[[Adenoid cystic carcinoma of the breast]]'' for the [[breast]] tumour.
{{Main|Adenoid cystic carcinoma}}
{{Main|Adenoid cystic carcinoma}}
Note: The [[breast]] tumour is dealt with in ''[[adenoid cystic carcinoma of the breast]]''.


==Salivary duct carcinoma==
==Salivary duct carcinoma==
{{Main|Salivary duct carcinoma}}
{{Main|Salivary duct carcinoma}}


==Polymorphous low-grade adenocarcinoma==
==Intraductal carcinoma of the salivary gland==
*Abbreviated ''PLGA''.
{{Main|Intraductal carcinoma of the salivary gland}}
{{Main|Polymorphous low-grade adenocarcinoma}}
 
==Polymorphous adenocarcinoma==
*Abbreviated ''PAC''.
*Previously known as ''polymorphous low-grade adenocarcinoma'', abbreviated ''PLGA''.
{{Main|Polymorphous adenocarcinoma}}


==Carcinoma ex pleomorphic adenoma==
==Carcinoma ex pleomorphic adenoma==
Michael
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