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The '''salivary glands''' help digest food. ENT surgeons | [[Image:Blausen_0780_SalivaryGlands.png|thumb|300px|Schematic showing the major salivary glands. (WC)]] | ||
The '''salivary glands''' help digest food. ENT surgeons excise them if a malignancy is suspected. | |||
The [[cytopathology]] of the salivary glands is covered in the ''[[Head and neck cytopathology]]'' article. | |||
=Normal salivary glands= | =Normal salivary glands= | ||
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| [[basal cell adenoma]] | | [[basal cell adenoma]] | ||
| exclusively oral cavity, 80% in upper lip; IHC: p63- | | exclusively oral cavity, 80% in upper lip; IHC: p63- | ||
| [ | | [[Image:Canalicular_adenoma_--_high_mag.jpg | thumb | center |150px| CA. (WC)]] | ||
|- | |- | ||
|[[Sialoblastoma]] | |[[Sialoblastoma]] | ||
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|- | |- | ||
|[[Adenoid cystic carcinoma]] (AdCC) | |[[Adenoid cystic carcinoma]] (AdCC) | ||
| pseudocysts,<br>'''cribriform''', solid,<br>hyaline stroma | | pseudocysts,<br>'''[[cribriform]]''', solid,<br>hyaline stroma | ||
| epithelioid | | epithelioid | ||
| subtle | | subtle | ||
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|- | |- | ||
|[[Salivary duct carcinoma]] | |[[Salivary duct carcinoma]] | ||
| glandular, cribriform | | glandular, [[cribriform]] | ||
| columnar | | columnar | ||
| subtle/clear | | subtle/clear | ||
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| ovoid & small with<br>small nucleoli | | ovoid & small with<br>small nucleoli | ||
| AdCC | | AdCC | ||
| minor salivary gland tumour,<br>often in palate,<br> cytologically monotonous; IHC: | | minor salivary gland tumour,<br>often in palate,<br> cytologically monotonous; IHC: [[S-100]]+, CK+, vim.+, GFAP+/-, BCL2+/- | ||
| [[Image:Polymorphous_low-grade_adenocarcinoma_-_very_low_mag.jpg|thumb|center|150px|PLGA. (WC/Nephron)]] | | [[Image:Polymorphous_low-grade_adenocarcinoma_-_very_low_mag.jpg|thumb|center|150px|PLGA. (WC/Nephron)]] | ||
|- | |- | ||
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*Metastatic [[clear cell carcinoma]]. | *Metastatic [[clear cell carcinoma]]. | ||
**Metastatic [[clear cell renal cell carcinoma]]. | **Metastatic [[clear cell renal cell carcinoma]]. | ||
===Basaloid neoplasms=== | |||
*[[Basal cell adenoma]]. | |||
*[[Basal cell adenocarcinoma]] | |||
*[[Pleomorphic adenoma]].<ref name=pmi12478487/> | |||
*[[Adenoid cystic carcinoma]].<ref name=pmi12478487/> | |||
*[[Small cell carcinoma]].<ref name=pmi12478487>{{Cite journal | last1 = Chhieng | first1 = DC. | last2 = Paulino | first2 = AF. | title = Basaloid tumors of the salivary glands. | journal = Ann Diagn Pathol | volume = 6 | issue = 6 | pages = 364-72 | month = Dec | year = 2002 | doi = 10.1053/adpa.2002.37013 | PMID = 12478487 }}</ref> | |||
==IHC overview== | ==IHC overview== | ||
General: | General: | ||
*Usually has limited value. | *Usually has limited value. <!--as per Ilan Weinreb--> | ||
Overview: | |||
*Luminal markers: CK7, CK19, CAM5.2 (LMWK). | *Luminal markers: [[CK7]], [[CK19]], CAM5.2 (LMWK). | ||
*Basal markers: p63, HMWK, CK14. | *Basal markers: p63, HMWK, CK14. | ||
*Myoepithelial markers: calponin, actin. | *Myoepithelial markers: calponin, actin. | ||
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Notes: | Notes: | ||
*p63 and S-100 are sometimes call myoepithelial. | *p63 and S-100 are sometimes call myoepithelial. | ||
Specifics: | |||
*Calponin, S-100, Ki-67 may be useful as per Nagao ''et al.''<ref>{{Cite journal | last1 = Nagao | first1 = T. | last2 = Sato | first2 = E. | last3 = Inoue | first3 = R. | last4 = Oshiro | first4 = H. | last5 = H Takahashi | first5 = R. | last6 = Nagai | first6 = T. | last7 = Yoshida | first7 = M. | last8 = Suzuki | first8 = F. | last9 = Obikane | first9 = H. | title = Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. | journal = Acta Histochem Cytochem | volume = 45 | issue = 5 | pages = 269-82 | month = Oct | year = 2012 | doi = 10.1267/ahc.12019 | PMID = 23209336 }}</ref> | |||
=Benign= | =Benign= | ||
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*Luminal stains +ve: CK7 +ve, CAM5.2 +ve. | *Luminal stains +ve: CK7 +ve, CAM5.2 +ve. | ||
*p63 +ve -- basal component. | *p63 +ve -- basal component. | ||
* | *[[S-100]] +ve -- spindle cells in the stroma. | ||
==Canalicular adenoma== | ==Canalicular adenoma== | ||
{{Main|Canalicular adenoma}} | |||
==Warthin tumour== | ==Warthin tumour== | ||
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==Sebaceous lymphadenoma== | ==Sebaceous lymphadenoma== | ||
{{Main|Sebaceous lymphadenoma}} | |||
==Oncocytoma of the salivary gland== | ==Oncocytoma of the salivary gland== | ||
*[[AKA]] ''salivary gland oncocytoma''. | *[[AKA]] ''salivary gland oncocytoma''. | ||
{{Main|Oncocytoma of the salivary gland}} | |||
=Malignant= | =Malignant= | ||
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==Adenoid cystic carcinoma== | ==Adenoid cystic carcinoma== | ||
{{Main|Adenoid cystic carcinoma}} | {{Main|Adenoid cystic carcinoma}} | ||
Note: The [[breast]] tumour is dealt with in ''[[adenoid cystic carcinoma of the breast]]''. | |||
==Salivary duct carcinoma== | ==Salivary duct carcinoma== | ||
{{Main|Salivary duct carcinoma}} | {{Main|Salivary duct carcinoma}} | ||
==Intraductal carcinoma of the salivary gland== | |||
{{Main|Intraductal carcinoma of the salivary gland}} | |||
==Polymorphous low-grade adenocarcinoma== | ==Polymorphous low-grade adenocarcinoma== |
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