SMARCB1-deficient sinonasal carcinoma
SMARCB1-deficient sinonasal carcinoma is a rare malignant tumour of the head and neck with loss of SMARCB1 staining.[1]
Microscopic
Features:[1]
- Pagetoid spread of plasmacytoid or rhabdoid cells.
- Cyst/pseudocyst like spaces.
- Lack squamous dysplasia.
- Lack of carcinoma-in-situ.
DDx:
IHC
- SMARCB1 (INI1) -ve.[1]
See also
References
- ↑ 1.0 1.1 1.2 Agaimy, A.; Hartmann, A.; Antonescu, CR.; Chiosea, SI.; El-Mofty, SK.; Geddert, H.; Iro, H.; Lewis, JS. et al. (Apr 2017). "SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity.". Am J Surg Pathol 41 (4): 458-471. doi:10.1097/PAS.0000000000000797. PMID 28291122.