Difference between revisions of "SMARCB1-deficient sinonasal carcinoma"

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==Microscopic==
==Microscopic==
Features:<ref name=pmid28291122/>
Features:<ref name=pmid28291122/>
*Pagetoid spread.
*Pagetoid spread of plasmacytoid or rhabdoid cells.
*Cyst/pseudocyst like spaces.
*Lack squamous dysplasia.
*Lack of carcinoma in situ.


DDx:
DDx:

Revision as of 04:25, 18 March 2019

SMARCB1-deficient sinonasal carcinoma is a rare malignant tumour of the head and neck with loss of SMARCB1 staining.[1]

Microscopic

Features:[1]

  • Pagetoid spread of plasmacytoid or rhabdoid cells.
  • Cyst/pseudocyst like spaces.
  • Lack squamous dysplasia.
  • Lack of carcinoma in situ.

DDx:

IHC

  • SMARCB1 (INI1) -ve.[1]

See also

References

  1. 1.0 1.1 1.2 Agaimy, A.; Hartmann, A.; Antonescu, CR.; Chiosea, SI.; El-Mofty, SK.; Geddert, H.; Iro, H.; Lewis, JS. et al. (Apr 2017). "SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity.". Am J Surg Pathol 41 (4): 458-471. doi:10.1097/PAS.0000000000000797. PMID 28291122.