SMARCA4-deficient sinonasal carcinoma

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SMARCA4-deficient sinonasal carcinoma is an emerging type of sinonasal carcinoma.[1]

General

Microscopic

Features:

  • Poorly differentiated tumour with large or small cells.

DDx:[2]

IHC

Features:[1]

  • SMARCA4 loss of staining - definitional.
  • CK5 -ve.
  • p63 -ve.
  • p16 -ve.
  • NUT -ve.

See also

References

  1. 1.0 1.1 "SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI/SNF-driven Sinonasal Malignancies". Am J Surg Pathol 44 (5): 703–710. May 2020. doi:10.1097/PAS.0000000000001428. PMID 31934917.
  2. 2.0 2.1 Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D (September 2022). "SMARCA4/BRG1-Deficient Sinonasal Carcinoma". Arch Pathol Lab Med 146 (9): 1122–1130. doi:10.5858/arpa.2021-0001-OA. PMID 34871352.