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Difference between revisions of "Rosai-Dorfman disease"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Emperipolesis_-_very_high_mag.jpg | | Image = Emperipolesis_-_very_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = Rosai-Dorfman disease. H&E stain. | | Caption = Rosai-Dorfman disease. H&E stain. | ||
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| LMDDx = other specific [[histiocytoses]] ([[Langerhans cell histiocytosis]], [[Erdheim-Chester disease]]), specific infections ([[rhinoscleroma]], [[xanthogranulomatous pyelonephritis]]), [[sinus histiocytosis]] | | LMDDx = other specific [[histiocytoses]] ([[Langerhans cell histiocytosis]], [[Erdheim-Chester disease]]), specific infections ([[rhinoscleroma]], [[xanthogranulomatous pyelonephritis]]), [[sinus histiocytosis]] | ||
| Stains = | | Stains = | ||
| IHC = CD68 | | IHC = CD68 +ve, S-100 +ve, CD1a -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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****Prominent nucleolus - visible with 10x objective. | ****Prominent nucleolus - visible with 10x objective. | ||
***Abundant cytoplasm. | ***Abundant cytoplasm. | ||
*Emperipolesis (from ''Greek'': ''em'' = inside, ''peri'' = around, ''polemai'' = wander about<ref>Stedman's Medical Dictionary. 27th Ed.</ref>): | *[[Emperipolesis]] (from ''Greek'': ''em'' = inside, ''peri'' = around, ''polemai'' = wander about<ref>Stedman's Medical Dictionary. 27th Ed.</ref>): | ||
**Histiocytes contain other whole cells: neutrophils, lymphocytes, plasma cells. | **Histiocytes contain other whole cells: neutrophils, lymphocytes, plasma cells. | ||
***The "eaten" cell is within a vacuole;<ref>{{cite journal |author=Viswanathan P, Raghunathan K, Majhi U, Pandit RV, Shanthi R, Rajkumar T|title=Emperipolesis : an electron microscopic characteristic in RDD (Rosai-Dorfaman disease) : a case report |volume= |issue=1|pages=14-6 |year=1997 |month= |pmid= |doi= |url=http://www.ijmpo.org/article.asp?issn=0971-5851;year=1997;volume=18;issue=1;spage=14;epage=16;aulast=Viswanathan;type=0}}</ref> thus, it should have a clear halo around it. | ***The "eaten" cell is within a vacuole;<ref>{{cite journal |author=Viswanathan P, Raghunathan K, Majhi U, Pandit RV, Shanthi R, Rajkumar T|title=Emperipolesis : an electron microscopic characteristic in RDD (Rosai-Dorfaman disease) : a case report |volume= |issue=1|pages=14-6 |year=1997 |month= |pmid= |doi= |url=http://www.ijmpo.org/article.asp?issn=0971-5851;year=1997;volume=18;issue=1;spage=14;epage=16;aulast=Viswanathan;type=0}}</ref> thus, it should have a clear halo around it. | ||
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===Images=== | ===Images=== | ||
====Case 1==== | |||
<gallery> | <gallery> | ||
Image:Emperipolesis_-_very_high_mag.jpg | Emperipolesis in SHML (WC) | Image:Emperipolesis_-_very_high_mag.jpg | Emperipolesis in SHML (WC) | ||
Image:Rosai-Dorfman_disease_-_very_high_mag.jpg | Rosai-Dorfman disease (WC) | Image:Rosai-Dorfman_disease_-_very_high_mag.jpg | Rosai-Dorfman disease (WC) | ||
</gallery> | </gallery> | ||
www | ====Case 2==== | ||
<gallery> | |||
Image: Rosai-Dorfman disease of parotid gland -- low mag.jpg | RDD - low mag. | |||
Image: Rosai-Dorfman disease of parotid gland -- intermed mag.jpg | RDD - intermed. mag. | |||
Image: Rosai-Dorfman disease of parotid gland -- high mag.jpg | RDD - high mag. | |||
Image: Rosai-Dorfman disease of parotid gland - alt -- high mag.jpg | RDD - high mag. | |||
Image: Rosai-Dorfman disease of parotid gland -- very high mag.jpg | RDD - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://path.upmc.edu/cases/case318.html RDD - case 1 - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case318.html RDD - case 1 - several images (upmc.edu)]. | ||
*[http://path.upmc.edu/cases/case338.html RDD - case 2 - several images of breast (upmc.edu)]. | *[http://path.upmc.edu/cases/case338.html RDD - case 2 - several images of breast (upmc.edu)]. | ||
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*CD1a -ve. | *CD1a -ve. | ||
**CD1a +ve in [[Langerhans cell histiocytosis]]. | **CD1a +ve in [[Langerhans cell histiocytosis]]. | ||
===Images=== | |||
<gallery> | |||
Image:Rosai-dorfman.jpg | Rosai-Dorfman disease - S-100 showing emperipolesis (WC/AFIP) | |||
</gallery> | |||
==See also== | ==See also== | ||