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Difference between revisions of "Rhabdomyosarcoma"
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#*General: may mimic [[leiomyosarcoma]] -- which is not common in the pediatric population. | #*General: may mimic [[leiomyosarcoma]] -- which is not common in the pediatric population. | ||
#*Microscopic: vesicular growth pattern, spindle cells. | #*Microscopic: vesicular growth pattern, spindle cells. | ||
===Anaplasia=== | |||
Criteria: | |||
#Hyperchromatic nuclei with size variation greater or equal to 3x. | |||
#Multipolar (atypical) mitotic figures. | |||
Subclassification: | |||
#Focal - a few cells. | |||
#Diffuse - cluster or sheets of anaplasia. | |||
Notes: | |||
*Not subtle - can identify at low power. | |||
*Seen in 10-15% of RMS. | |||
**More common in older individuals. | |||
*Poorer prognosis in embryonal RMS. | |||
**No change in prognosis in alveolar RMS. | |||
==IHC== | ==IHC== | ||