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Renomedullary interstitial cell tumour (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Renal_medullary_fibroma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Renal medullary fibroma. [[H&E stain]]. | |||
| Synonyms = renal medullary fibroma | |||
| Micro = small polygonal/stellate cells in abundant loose/[[myxoid stroma]], +/-entrapped renal tubules | |||
| Subtypes = | |||
| LMDDx = renal myxoma, edge of medium-sized blood vessel | |||
| Stains = | |||
| IHC = alpha-SMA +ve, CD35 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = small (usu. <3 mm), white, well-circumscribed nodule - medulla of kidney | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[kidney tumours]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Renomedullary interstitial cell tumour''', also known as '''medullary fibroma''',<ref name=pmid11054036 >{{Cite journal | last1 = Bircan | first1 = S. | last2 = Orhan | first2 = D. | last3 = Tulunay | first3 = O. | last4 = Safak | first4 = M. | title = Renomedullary interstitial cell tumor. | journal = Urol Int | volume = 65 | issue = 3 | pages = 163-6 | month = | year = 2000 | doi = | PMID = 11054036 }}</ref> is a relatively common benign tumour of the kidney. | |||
==General== | |||
*Benign. | |||
*Common [[autopsy]] finding<ref name=Ref_WMSP295>{{Ref WMSP|295}}</ref> - one review says 26-41% of individuals at autopsy.<ref name=pmid10689882>{{Cite journal | last1 = Tsurukawa | first1 = H. | last2 = Iuchi | first2 = H. | last3 = Osanai | first3 = H. | last4 = Yamaguchi | first4 = S. | last5 = Hashimoto | first5 = H. | last6 = Kaneko | first6 = S. | last7 = Yachiku | first7 = S. | title = [Renomedullary interstitial cell tumor: a case report]. | journal = Nihon Hinyokika Gakkai Zasshi | volume = 91 | issue = 1 | pages = 37-40 | month = Jan | year = 2000 | doi = | PMID = 10689882 }}</ref> | |||
**The commonality is somewhat in dispute.<ref name=pmid18655367>{{Cite journal | last1 = Kozłowska | first1 = J. | last2 = Okoń | first2 = K. | title = Renal tumors in postmortem material. | journal = Pol J Pathol | volume = 59 | issue = 1 | pages = 21-5 | month = | year = 2008 | doi = | PMID = 18655367 }}</ref> | |||
==Gross== | |||
*Small, white well-circumscribed nodule in medulla. | |||
**Typically less than 3 mm.<ref name=pmid10689882/> | |||
Image: | |||
*[http://library.med.utah.edu/WebPath/RENAHTML/RENAL155.html Renal medullary fibroma (utah.edu)]. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP295>{{Ref WMSP|295}}</ref><ref>URL: [http://webpathology.com/image.asp?n=16&Case=71 http://webpathology.com/image.asp?n=16&Case=71]. Accessed on: 17 October 2011.</ref> | |||
*Small polygonal/stellate cells. | |||
*Abundant loose/[[myxoid stroma]]. | |||
*+/-Entrapped renal tubules.<ref name=pmid12066202>{{Cite journal | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month = | year = | doi = | PMID = 12066202 }}</ref> | |||
DDx: | |||
*Renal myxoma.<ref name=pmid8291657>{{Cite journal | last1 = Melamed | first1 = J. | last2 = Reuter | first2 = VE. | last3 = Erlandson | first3 = RA. | last4 = Rosai | first4 = J. | title = Renal myxoma. A report of two cases and review of the literature. | journal = Am J Surg Pathol | volume = 18 | issue = 2 | pages = 187-94 | month = Feb | year = 1994 | doi = | PMID = 8291657 }}</ref> | |||
*Edge of medium-sized blood vessel. | |||
===Images=== | |||
<gallery> | |||
Image:Renal_medullary_fibroma_-_low_mag.jpg | Renal medullary fibroma - low mag. (WC/Nephron) | |||
Image:Renal_medullary_fibroma_-_intermed_mag.jpg | Renal medullary fibroma - intermed. mag. (WC/Nephron) | |||
Image:Renal_medullary_fibroma_-_high_mag.jpg | Renal medullary fibroma - high mag. (WC/Nephron) | |||
Image:Renal_medullary_fibroma_-_very_high_mag.jpg | Renal medullary fibroma - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://webpathology.com/image.asp?case=71&n=15 Renomedullary interstitial cell tumour - low mag. (webpathology.com)]. | |||
*[http://webpathology.com/image.asp?n=16&Case=71 Renomedullary interstitial cell tumour - high mag. (webpathology.com)]. | |||
==IHC== | |||
Features:<ref name=pmid12066202>{{Cite journal | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month = | year = | doi = | PMID = 12066202 }}</ref> | |||
*Alpha-smooth muscle actin +ve. | |||
*CD35 +ve. | |||
==See also== | |||
*[[Kidney tumours]]. | |||
*[[Renal medullary carcinoma]]. | |||
*[[Renal medullary dysplasia]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Kidney tumours]] | |||