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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Renal_medullary_fibroma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Renal medullary fibroma. [[H&E stain]]. | |||
| Synonyms = renal medullary fibroma | |||
| Micro = small polygonal/stellate cells in abundant loose/[[myxoid stroma]], +/-entrapped renal tubules | |||
| Subtypes = | |||
| LMDDx = renal myxoma, edge of medium-sized blood vessel | |||
| Stains = | |||
| IHC = alpha-SMA +ve, CD35 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = small (usu. <3 mm), white, well-circumscribed nodule - medulla of kidney | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[kidney tumours]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Renomedullary interstitial cell tumour''', also known as '''medullary fibroma''',<ref name=pmid11054036 >{{Cite journal | last1 = Bircan | first1 = S. | last2 = Orhan | first2 = D. | last3 = Tulunay | first3 = O. | last4 = Safak | first4 = M. | title = Renomedullary interstitial cell tumor. | journal = Urol Int | volume = 65 | issue = 3 | pages = 163-6 | month = | year = 2000 | doi = | PMID = 11054036 }}</ref> is a relatively common benign tumour of the kidney. | '''Renomedullary interstitial cell tumour''', also known as '''medullary fibroma''',<ref name=pmid11054036 >{{Cite journal | last1 = Bircan | first1 = S. | last2 = Orhan | first2 = D. | last3 = Tulunay | first3 = O. | last4 = Safak | first4 = M. | title = Renomedullary interstitial cell tumor. | journal = Urol Int | volume = 65 | issue = 3 | pages = 163-6 | month = | year = 2000 | doi = | PMID = 11054036 }}</ref> is a relatively common benign tumour of the kidney. | ||
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*Abundant loose/[[myxoid stroma]]. | *Abundant loose/[[myxoid stroma]]. | ||
*+/-Entrapped renal tubules.<ref name=pmid12066202>{{Cite journal | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month = | year = | doi = | PMID = 12066202 }}</ref> | *+/-Entrapped renal tubules.<ref name=pmid12066202>{{Cite journal | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month = | year = | doi = | PMID = 12066202 }}</ref> | ||
DDx: | |||
*Renal myxoma.<ref name=pmid8291657>{{Cite journal | last1 = Melamed | first1 = J. | last2 = Reuter | first2 = VE. | last3 = Erlandson | first3 = RA. | last4 = Rosai | first4 = J. | title = Renal myxoma. A report of two cases and review of the literature. | journal = Am J Surg Pathol | volume = 18 | issue = 2 | pages = 187-94 | month = Feb | year = 1994 | doi = | PMID = 8291657 }}</ref> | |||
*Edge of medium-sized blood vessel. | |||
===Images=== | ===Images=== | ||
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Image:Renal_medullary_fibroma_-_low_mag.jpg | Renal medullary fibroma - low mag. (WC/Nephron) | Image:Renal_medullary_fibroma_-_low_mag.jpg | Renal medullary fibroma - low mag. (WC/Nephron) | ||
Image:Renal_medullary_fibroma_-_intermed_mag.jpg | Renal medullary fibroma - intermed. mag. (WC/Nephron) | Image:Renal_medullary_fibroma_-_intermed_mag.jpg | Renal medullary fibroma - intermed. mag. (WC/Nephron) | ||
Image:Renal_medullary_fibroma_-_high_mag.jpg | Renal medullary fibroma - high mag. (WC/Nephron) | |||
Image:Renal_medullary_fibroma_-_very_high_mag.jpg | Renal medullary fibroma - very high mag. (WC/Nephron) | Image:Renal_medullary_fibroma_-_very_high_mag.jpg | Renal medullary fibroma - very high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
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*[http://webpathology.com/image.asp?case=71&n=15 Renomedullary interstitial cell tumour - low mag. (webpathology.com)]. | *[http://webpathology.com/image.asp?case=71&n=15 Renomedullary interstitial cell tumour - low mag. (webpathology.com)]. | ||
*[http://webpathology.com/image.asp?n=16&Case=71 Renomedullary interstitial cell tumour - high mag. (webpathology.com)]. | *[http://webpathology.com/image.asp?n=16&Case=71 Renomedullary interstitial cell tumour - high mag. (webpathology.com)]. | ||
==IHC== | |||
Features:<ref name=pmid12066202>{{Cite journal | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month = | year = | doi = | PMID = 12066202 }}</ref> | |||
*Alpha-smooth muscle actin +ve. | |||
*CD35 +ve. | |||
==See also== | ==See also== | ||
*[[Kidney tumours]]. | *[[Kidney tumours]]. | ||
*[[Renal medullary carcinoma]]. | |||
*[[Renal medullary dysplasia]]. | |||
==References== | ==References== |
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