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Difference between revisions of "TFEB-rearranged renal cell carcinoma"
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TFEB-rearranged renal cell carcinoma (view source)
Revision as of 08:57, 8 September 2019
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It was added to WHO classification of renal neoplasia in the [[Vancouver classification|2012 Vancouver modification]].<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | It was added to WHO classification of renal neoplasia in the [[Vancouver classification|2012 Vancouver modification]].<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | ||
This entity should '''not''' be confused with [[TCEB1-mutated renal cell carcinoma]], | This entity should '''not''' be confused with [[TCEB1-mutated renal cell carcinoma]], a subset of [[clear cell carcinoma]] that is ''not'' an entity in the WHO classification of renal neoplasia. | ||
==General== | ==General== | ||
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*[[Renal cell carcinoma, unclassified]]. | *[[Renal cell carcinoma, unclassified]]. | ||
*[[Angiomyolipoma]] (epithelioid). | *[[Angiomyolipoma]] (epithelioid). | ||
*[[Clear cell renal cell carcinoma]] with eosinophilic cytoplasm. | |||
*Other [[renal tumours with eosinophilic cytoplasm]]. | *Other [[renal tumours with eosinophilic cytoplasm]]. | ||
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Image: TFEB-like renal cell carcinoma - gland-like -- high mag.jpg | TFEB-like RCC - high mag. | Image: TFEB-like renal cell carcinoma - gland-like -- high mag.jpg | TFEB-like RCC - high mag. | ||
</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
*TFEB +ve (nuclear staining). | *TFEB +ve (nuclear staining). | ||
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*RCC +ve (10 +ve of 14<ref name=pmid24618616/>). | *RCC +ve (10 +ve of 14<ref name=pmid24618616/>). | ||
*CD10 +ve (10 +ve of 14<ref name=pmid24618616/>). | *CD10 +ve (10 +ve of 14<ref name=pmid24618616/>). | ||
Note: | |||
*Melan A and HMB-45 are considered a good screen for this entity and recommended for renal tumour with eosinophilic cytoplasm. | |||
==Molecular== | ==Molecular== | ||