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Difference between revisions of "Renal cell carcinoma with fibromyomatous stroma"
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Renal cell carcinoma with fibromyomatous stroma (view source)
Revision as of 13:30, 26 March 2024
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'''Renal cell carcinoma with fibromyomatous stroma''', abbreviated '''RCC FMS''', is an evolving subtype of [[renal cell carcinoma]].<ref>{{cite journal |authors=Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O |title=Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |journal=Mod Pathol |volume=34 |issue=6 |pages=1167–1184 |date=June 2021 |pmid=33526874 |doi=10.1038/s41379-021-00737-6 |url=}}</ref> | '''Renal cell carcinoma with fibromyomatous stroma''', abbreviated '''RCC FMS''', is an evolving subtype of [[renal cell carcinoma]].<ref>{{cite journal |authors=Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O |title=Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |journal=Mod Pathol |volume=34 |issue=6 |pages=1167–1184 |date=June 2021 |pmid=33526874 |doi=10.1038/s41379-021-00737-6 |url=}}</ref> | ||
''Renal cell carcinoma with leiomyomatous stroma'' redirects here. | |||
==General== | |||
*Rare tumour: 12 in >500 renal cell carcinomas with clear cells.<ref name=pmid36592877/> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid36592877>{{cite journal |authors=Tjota MY, Sharma A, Wanjari P, Fitzpatrick C, Segal J, Antic T |title=TSC/MTOR mutated renal cell carcinoma with leiomyomatous stroma is a distinct entity: a comprehensive study of 12 cases |journal=Hum Pathol |volume=134 |issue= |pages=124–133 |date=April 2023 |pmid=36592877 |doi=10.1016/j.humpath.2022.12.015 |url=}}</ref> | ||
*Fibromyomatous stroma - '''key feature'''. | *Fibromyomatous stroma (smooth muscle stroma) - '''key feature'''. | ||
*Varied architecture: nested, solid, tubular, tubulopapillary. | |||
*WHO/ISUP grade 3 or 4. | |||
*Nuclei ''not'' polarized in the cell. | |||
DDx: | DDx: | ||
| Line 11: | Line 19: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid36592877/> | |||
*CD10 +ve. | |||
*CK7 +ve (most). | |||
*CA9 +ve. | |||
===Comparison between some renal tumours with clear cells=== | ===Comparison between some renal tumours with clear cells=== | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
| Line 17: | Line 30: | ||
!CD10 | !CD10 | ||
!CK34betaE12 (K903) | !CK34betaE12 (K903) | ||
!GPNMB | ![[GPNMB]] | ||
|- | |- | ||
|Clear cell renal cell carcinoma | |Clear cell renal cell carcinoma | ||
| Line 37: | Line 50: | ||
| -ve | | -ve | ||
|- | |- | ||
| | |Renal cell carcinoma with fibromyomatous stroma | ||
| +ve | | +ve | ||
| +ve | | +ve | ||
| Line 44: | Line 57: | ||
|- | |- | ||
|} | |} | ||
==Molecular== | |||
*[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutation]].<ref name=pmid36592877/> | |||
==See also== | ==See also== | ||
*[[Renal cell carcinoma]]. | *[[Renal cell carcinoma]]. | ||
*[[Clear cells in the kidney]]. | |||
==References== | ==References== | ||