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Difference between revisions of "Renal cell carcinoma grading"
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[[Image:Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg|right|thumb|ISUP nucleolar grade 2 in a [[renal cell carcinoma]]. [[H&E stain]].]] | |||
[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg|thumb|right|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]] | [[Image:Clear cell renal cell carcinoma -- intermed mag.jpg|thumb|right|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]] | ||
[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg|thumb|right| | [[Image:Renal cell carcinoma with rhabdoid change -- high mag.jpg|thumb|right|ISUP grade 4 is used for [[renal cell carcinoma with rhabdoid change]]. [[H&E stain]].]] | ||
[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg|thumb|right|ISUP nucleolar grade 4 is used for [[renal cell carcinoma with sarcomatoid differentiation]]. [[H&E stain]].]] | |||
This article deals with '''renal cell carcinoma grading'''. | This article deals with '''renal cell carcinoma grading'''. | ||
''Fuhrman grading'' | ''Fuhrman grading'', ''ISUP grading'', ''ISUP nucleolar grading'' and ''kidney cancer grading'' redirect here. | ||
==General== | ==General== | ||
There are two systems: | There are two systems: | ||
*''[[ISUP]] grading'':<ref name=pmid24025520>{{cite journal |author=Delahunt B, Cheville JC, Martignoni G, ''et al.'' |title=The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters |journal=Am. J. Surg. Pathol. |volume=37 |issue=10 |pages=1490–504 |year=2013 |month=October |pmid=24025520 |doi=10.1097/PAS.0b013e318299f0fb |url=}}</ref> | |||
**Newer and less complicated. | |||
**Mostly based on [[nucleoli|nucleolar size]] and to a much lesser degree on size and morphology | |||
**Developed based on ''Fuhrman grading'' | |||
**Prognostic value demonstrated in a larger cohort by Dagher ''et al.''<ref name=pmid28718911>{{Cite journal | last1 = Dagher | first1 = J. | last2 = Delahunt | first2 = B. | last3 = Rioux-Leclercq | first3 = N. | last4 = Egevad | first4 = L. | last5 = Srigley | first5 = JR. | last6 = Coughlin | first6 = G. | last7 = Dunglinson | first7 = N. | last8 = Gianduzzo | first8 = T. | last9 = Kua | first9 = B. | title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. | journal = Histopathology | volume = 71 | issue = 6 | pages = 918-925 | month = Dec | year = 2017 | doi = 10.1111/his.13311 | PMID = 28718911 }}</ref> | |||
*''Fuhrman grading'': | *''Fuhrman grading'': | ||
**Older and more complicated. | **Older and more complicated. | ||
**Based on nuclear size and shape, chromatin pattern and [[nucleoli|nucleolar size]].<ref name=Ref_GUP282>{{Ref GUP|282}}</ref> | **Based on nuclear size and shape, chromatin pattern and [[nucleoli|nucleolar size]].<ref name=Ref_GUP282>{{Ref GUP|282}}</ref> | ||
==ISUP grading== | ==ISUP grading== | ||
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*[[Renal cell carcinoma]]. | *[[Renal cell carcinoma]]. | ||
*[[Kidney tumours]]. | *[[Kidney tumours]]. | ||
*[[Renal cell carcinoma with rhabdoid change]]. | |||
==References== | ==References== | ||