Difference between revisions of "Rectal prolapse"

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===Micro===
====Micro====
The sections show rectal mucosa, submucosa and a small amount of muscularis propria.  The mucosa shows fibromuscular hyperplasia with thickening of the muscularis mucosae and mild lamina propria fibrosis. The submucosa is edematous. The small amount of muscularis propria is unremarkable. The epithelium matures normally to the surface. No significant nuclear atypia is identified.
The sections show rectal mucosa, submucosa and a small amount of muscularis propria.  The mucosa shows fibromuscular hyperplasia with thickening of the muscularis mucosae and mild lamina propria fibrosis. The submucosa is edematous. The small amount of muscularis propria is unremarkable. The epithelium matures normally to the surface. No significant nuclear atypia is identified.
===Ischemic changes present===
<pre>
RECTAL MUCOSA, DELORME PROCEDURE:
- SUPERFICIAL RECTAL WALL WITH REACTIVE CHANGES, ISCHEMIC CHANGES AND FIBROMUSCULAR
  HYPERPLASIA, SEE COMMENT.
- NEGATIVE FOR MALIGNANCY.
COMMENT:
The changes are compatible with prolapse (fibromuscular hyperplasia) and suggestive of
concurrent ischemia (see microscopic).
The mucosal reactive changes are marked. No definite dysplasia is identified; however, it
is difficult to completely exclude. Follow-up is recommended.
</pre>
====Micro====
The sections show superficial rectal wall with ischemic changes (focal cryptitis, marked
reactive epithelial changes, erosions, capillary congestion, goblet cell paucitity,
epithelium with attenuated cytoplasm) and changes compatible with prolapse (fibromuscular
hyperplasia).


==See also==
==See also==

Revision as of 17:30, 31 December 2013

Rectal prolapse
Diagnosis in short

Fibromuscular hyperplasia as seen in rectal prolapse. H&E stain.

LM fibromuscular hyperplasia: lamina propria fibrosis and lamina propria muscle, thick muscularis propria, submucosal fibrosis, +/-ischemic mucosal changes
Site rectum

Clinical history women - multiparous & postmenopausal
Signs "rectal mass"
Prevalence not common
Prognosis benign
Clin. DDx rectal carcinoma (rarely)
Treatment surgery

Rectal prolapse is a benign pathology of the rectum, typically seen in women that are multiparous and postmenopausal.

General

  • Usually close to the anal verge.
  • Rare forms can occasionally be confused with cancer.[1]

Epidemiology:

  • ~90% women, postmenopausal and multiparous.[2]

Treatment:

  • Surgical:
    • Delorme procedure = mucosa stripped.

Microscopic

Features:[3]

  • "Fibromuscular hyperplasia" - key feature:
    • Fibrosis (submucosa, lamina propria).
    • Muscularis mucosae is "too superficial" (muscle in the lamina propria).
  • Surface ulceration + inflammation (neutrophils).
  • +/-Serration of epithelium at the surface.

Notes:

  • Important negative: no nuclear atypia.
    • May be seen if ischemic changes are present.

Images

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RECTAL MUCOSA, DELORME PROCEDURE:
- SUPERFICIAL RECTAL WALL WITH FIBROMUSCULAR HYPERPLASIA AND EDEMA.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. 

Micro

The sections show rectal mucosa, submucosa and a small amount of muscularis propria. The mucosa shows fibromuscular hyperplasia with thickening of the muscularis mucosae and mild lamina propria fibrosis. The submucosa is edematous. The small amount of muscularis propria is unremarkable. The epithelium matures normally to the surface. No significant nuclear atypia is identified.

Ischemic changes present

RECTAL MUCOSA, DELORME PROCEDURE:
- SUPERFICIAL RECTAL WALL WITH REACTIVE CHANGES, ISCHEMIC CHANGES AND FIBROMUSCULAR
  HYPERPLASIA, SEE COMMENT.
- NEGATIVE FOR MALIGNANCY.

COMMENT:
The changes are compatible with prolapse (fibromuscular hyperplasia) and suggestive of
concurrent ischemia (see microscopic).

The mucosal reactive changes are marked. No definite dysplasia is identified; however, it
is difficult to completely exclude. Follow-up is recommended.

Micro

The sections show superficial rectal wall with ischemic changes (focal cryptitis, marked reactive epithelial changes, erosions, capillary congestion, goblet cell paucitity, epithelium with attenuated cytoplasm) and changes compatible with prolapse (fibromuscular hyperplasia).

See also

References

  1. Brosens LA, Montgomery EA, Bhagavan BS, Offerhaus GJ, Giardiello FM (November 2009). "Mucosal prolapse syndrome presenting as rectal polyposis". J. Clin. Pathol. 62 (11): 1034–6. doi:10.1136/jcp.2009.067801. PMC 2853932. PMID 19861563. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853932/.
  2. Lee, S.; Kye, BH.; Kim, HJ.; Cho, HM.; Kim, JG. (Feb 2012). "Delorme's Procedure for Complete Rectal Prolapse: Does It Still Have It's Own Role?". J Korean Soc Coloproctol 28 (1): 13-8. doi:10.3393/jksc.2012.28.1.13. PMID 22413077.
  3. Schneider A, Fritze C, Bosseckert H, Machnik G (1988). "[Primary clinical, endoscopic and histologic findings in solitary rectal ulcer]" (in German). Dtsch Z Verdau Stoffwechselkr 48 (3-4): 183–9. PMID 3234303.