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Difference between revisions of "Radiation changes"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Radiation changes -- high mag.jpg | | Image = Radiation changes -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = Radiation changes. [[H&E stain]]. | | Caption = Radiation changes. [[H&E stain]]. | ||
| Micro = cytoplasmic vacuolation (usually abundant), enlarged nuclei - but usu. normal [[NC ratio]], no nuclear membrane irregularies, chromatin "smudgy", +/-multinucleation, +/-fibrosis (chronic change), +/-edema (acute change) | | Micro = cytoplasmic vacuolation (usually abundant), enlarged nuclei - but usu. normal [[NC ratio]], no nuclear membrane irregularies, chromatin "smudgy", +/-multinucleation, +/-fibrosis (chronic change), +/-edema (acute change) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[pleomorphic tumours]] - esp. [[sarcoma]]s, poorly differentiated carcinomas, drug/toxin effect | | LMDDx = [[pleomorphic tumours]] - esp. [[sarcoma]]s, poorly differentiated carcinomas, drug/toxin effect, well-differentiated tumours in the background of radiation changes, "[[giant cell cystitis]]" | ||
| Stains = | | Stains = | ||
| IHC = Ki-67 low, pankeratin -ve (usu.) | | IHC = Ki-67 low, pankeratin -ve (usu.) | ||
| Line 55: | Line 55: | ||
DDx: | DDx: | ||
*[[Pleomorphic tumours]]. | *[[Pleomorphic tumours]]. | ||
*Well-differentiated carcinoma, e.g. [[postradiation prostatic carcinoma]], may go unnoticed in the background of radiation-associated atypia. | *Well-differentiated carcinoma, e.g. [[postradiation prostatic carcinoma]], may go unnoticed in the background of radiation-associated nuclear changes. | ||
*Atypia associated with [[drug toxicity|drugs]]. | |||
*"[[Giant cell cystitis]]" - benign mesenchymal atypia with or without inflammation. | |||
===Images=== | ===Images=== | ||
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Image: Prostate with radiation changes -- intermed mag.jpg | Prostate with RC - intermed. mag. | Image: Prostate with radiation changes -- intermed mag.jpg | Prostate with RC - intermed. mag. | ||
Image: Prostate with radiation changes -- high mag.jpg | Prostate with RC - high mag. | Image: Prostate with radiation changes -- high mag.jpg | Prostate with RC - high mag. | ||
</gallery> | |||
====Brain==== | |||
<gallery> | |||
File:Glioblastoma-radiation changes HE.jpg | [[Glioblastoma]] with RC (WC/jensflorian) | |||
File:Pathology Brain Radiation Necrosis 1.jpg | Radiation necrosis (WC/Tdvorak) | |||
File:Pathology Brain Radiation Necrosis 2.jpg | Radiation necrosis and gliosis (WC/Tdvorak) | |||
</gallery> | </gallery> | ||
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==See also== | ==See also== | ||
*[[Radiation colitis]]. | *[[Radiation colitis]]. | ||
*[[Radiation esophagitis]]. | |||
*[[Radiation changes in cervical cytology]]. | *[[Radiation changes in cervical cytology]]. | ||
*[[Radiation changes of the endocervical epithelium]]. | *[[Radiation changes of the endocervical epithelium]]. | ||