48,460
edits
(16 intermediate revisions by 2 users not shown) | |||
Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Radiation changes -- high mag.jpg | | Image = Radiation changes -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = Radiation changes. [[H&E stain]]. | | Caption = Radiation changes. [[H&E stain]]. | ||
| Micro = cytoplasmic vacuolation (usually abundant), enlarged nuclei - but usu. normal [[NC ratio]], no nuclear membrane irregularies, chromatin "smudgy", +/-multinucleation, +/-fibrosis (chronic change), +/-edema (acute change) | | Micro = cytoplasmic vacuolation (usually abundant), enlarged nuclei - but usu. normal [[NC ratio]], no nuclear membrane irregularies, chromatin "smudgy", +/-multinucleation, +/-fibrosis (chronic change), +/-edema (acute change) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[pleomorphic tumours]] - esp. [[sarcoma]]s, poorly differentiated carcinomas, drug/toxin effect | | LMDDx = [[pleomorphic tumours]] - esp. [[sarcoma]]s, poorly differentiated carcinomas, drug/toxin effect, well-differentiated tumours in the background of radiation changes, "[[giant cell cystitis]]" | ||
| Stains = | | Stains = | ||
| IHC = Ki-67 low, pankeratin -ve (usu.) | | IHC = Ki-67 low, pankeratin -ve (usu.) | ||
Line 26: | Line 26: | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = cancer recurrence, infection, new malignancy, post-surgical changes | ||
}} | }} | ||
'''Radiation changes''', also '''radiation | '''Radiation changes''', also '''radiation effects''', are seen occasionally by [[pathologist]]s. They are usually a result of prior (radiation) treatments. The history is important in making this [[diagnosis]]. | ||
==General== | |||
*History of radiation treatment/exposure. | |||
*Clinical symptoms dependent on site. | |||
==Gross== | ==Gross== | ||
Line 51: | Line 55: | ||
DDx: | DDx: | ||
*[[Pleomorphic tumours]]. | *[[Pleomorphic tumours]]. | ||
*Well-differentiated carcinoma, e.g. [[postradiation prostatic carcinoma]], may go unnoticed in the background of radiation-associated nuclear changes. | |||
*Atypia associated with [[drug toxicity|drugs]]. | |||
*"[[Giant cell cystitis]]" - benign mesenchymal atypia with or without inflammation. | |||
===Images=== | ===Images=== | ||
====Rectum==== | |||
<gallery> | <gallery> | ||
Image: Radiation proctitis - alt -- low mag.jpg | [[Radiation proctitis]] - low mag. (WC) | Image: Radiation proctitis - alt -- low mag.jpg | [[Radiation proctitis]] - low mag. (WC) | ||
Line 61: | Line 69: | ||
Image: Radiation proctitis - 2 -- high mag.jpg | Radiation proctitis - high mag. (WC) | Image: Radiation proctitis - 2 -- high mag.jpg | Radiation proctitis - high mag. (WC) | ||
Image: Radiation proctitis - 2 alt -- high mag.jpg | Radiation proctitis - high mag. (WC) | Image: Radiation proctitis - 2 alt -- high mag.jpg | Radiation proctitis - high mag. (WC) | ||
</gallery> | |||
====Prostate gland==== | |||
<gallery> | |||
Image: Prostate with radiation changes -- low mag.jpg | Prostate with RC - low mag. | |||
Image: Prostate with radiation changes -- intermed mag.jpg | Prostate with RC - intermed. mag. | |||
Image: Prostate with radiation changes -- high mag.jpg | Prostate with RC - high mag. | |||
</gallery> | |||
====Brain==== | |||
<gallery> | |||
File:Glioblastoma-radiation changes HE.jpg | [[Glioblastoma]] with RC (WC/jensflorian) | |||
File:Pathology Brain Radiation Necrosis 1.jpg | Radiation necrosis (WC/Tdvorak) | |||
File:Pathology Brain Radiation Necrosis 2.jpg | Radiation necrosis and gliosis (WC/Tdvorak) | |||
</gallery> | </gallery> | ||
Line 99: | Line 120: | ||
==See also== | ==See also== | ||
*[[Radiation colitis]]. | *[[Radiation colitis]]. | ||
*[[Radiation esophagitis]]. | |||
*[[Radiation changes in cervical cytology]]. | *[[Radiation changes in cervical cytology]]. | ||
*[[Radiation changes of the endocervical epithelium]]. | *[[Radiation changes of the endocervical epithelium]]. | ||
*[[Radiation oncology]]. | *[[Radiation oncology]]. | ||
*[[Endometrium post-ablation]]. | |||
==References== | ==References== |
edits