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Difference between revisions of "Radiation changes"
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| Micro = cytoplasmic vacuolation (usually abundant), enlarged nuclei - but usu. normal [[NC ratio]], no nuclear membrane irregularies, chromatin "smudgy", +/-multinucleation, +/-fibrosis (chronic change), +/-edema (acute change) | | Micro = cytoplasmic vacuolation (usually abundant), enlarged nuclei - but usu. normal [[NC ratio]], no nuclear membrane irregularies, chromatin "smudgy", +/-multinucleation, +/-fibrosis (chronic change), +/-edema (acute change) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[pleomorphic tumours]] - esp. [[sarcoma]]s, poorly differentiated carcinomas, drug/toxin effect | | LMDDx = [[pleomorphic tumours]] - esp. [[sarcoma]]s, poorly differentiated carcinomas, drug/toxin effect, well-differentiated tumours in the background of radiation changes | ||
| Stains = | | Stains = | ||
| IHC = Ki-67 low, pankeratin -ve (usu.) | | IHC = Ki-67 low, pankeratin -ve (usu.) | ||
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*[[Pleomorphic tumours]]. | *[[Pleomorphic tumours]]. | ||
*Well-differentiated carcinoma, e.g. [[postradiation prostatic carcinoma]], may go unnoticed in the background of radiation-associated nuclear changes. | *Well-differentiated carcinoma, e.g. [[postradiation prostatic carcinoma]], may go unnoticed in the background of radiation-associated nuclear changes. | ||
*Atypia associated with [[drug toxicity|drugs]]. | |||
===Images=== | ===Images=== | ||