Pulmonary neuroendocrine cell hyperplasia

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Pulmonary neuroendocrine cell hyperplasia is a proliferation of neuroendocrine cells confined by the bronchial basement membrane.

General

  • Common.

Microscopic

Features:

  • Neuroendocrine cells.
    • Salt and pepper chromatin.
  • Arranged linearly along the bronchus - confined by the basement membrane.[1]

DDx:

  • Carcinoid tumourlet - extends beyond the basement membrane and less than 5 mm in maximal dimension.

References

  1. ↑ Koo, CW.; Baliff, JP.; Torigian, DA.; Litzky, LA.; Gefter, WB.; Akers, SR. (Sep 2010). "Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids.". AJR Am J Roentgenol 195 (3): 661-8. doi:10.2214/AJR.09.3811. PMID 20729444.
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