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Difference between revisions of "Pulmonary hamartoma"
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*Malignant transformation reported.<ref name=pmid21220977>{{Cite journal | last1 = Lee | first1 = BJ. | last2 = Kim | first2 = HR. | last3 = Cheon | first3 = GJ. | last4 = Koh | first4 = JS. | last5 = Kim | first5 = CH. | last6 = Lee | first6 = JC. | title = Squamous cell carcinoma arising from pulmonary hamartoma. | journal = Clin Nucl Med | volume = 36 | issue = 2 | pages = 130-1 | month = Feb | year = 2011 | doi = 10.1097/RLU.0b013e318203bc27 | PMID = 21220977 }}</ref> | *Malignant transformation reported.<ref name=pmid21220977>{{Cite journal | last1 = Lee | first1 = BJ. | last2 = Kim | first2 = HR. | last3 = Cheon | first3 = GJ. | last4 = Koh | first4 = JS. | last5 = Kim | first5 = CH. | last6 = Lee | first6 = JC. | title = Squamous cell carcinoma arising from pulmonary hamartoma. | journal = Clin Nucl Med | volume = 36 | issue = 2 | pages = 130-1 | month = Feb | year = 2011 | doi = 10.1097/RLU.0b013e318203bc27 | PMID = 21220977 }}</ref> | ||
*Typically an incidental (radiologic) finding.<ref>{{Cite journal | last1 = Yang | first1 = C. | last2 = Zhao | first2 = H. | last3 = Yin | first3 = H. | title = [Diagnosis and treatment of pulmonary hamartoma]. | journal = Zhonghua Jie He He Hu Xi Za Zhi | volume = 22 | issue = 7 | pages = 399-400 | month = Jul | year = 1999 | doi = | PMID = 11775809 }}</ref> | *Typically an incidental (radiologic) finding.<ref>{{Cite journal | last1 = Yang | first1 = C. | last2 = Zhao | first2 = H. | last3 = Yin | first3 = H. | title = [Diagnosis and treatment of pulmonary hamartoma]. | journal = Zhonghua Jie He He Hu Xi Za Zhi | volume = 22 | issue = 7 | pages = 399-400 | month = Jul | year = 1999 | doi = | PMID = 11775809 }}</ref> | ||
*Treatment: surgical resection. | |||
==Gross== | ==Gross== | ||
*Well circumscribed lesion. | *Well circumscribed lesion. | ||
*Varied morphology. | |||
===Radiology=== | ===Radiology=== | ||
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DDx: | DDx: | ||
*Other [[lung tumours]] - especially slow growing ones. | *Other [[lung tumours]] - especially slow growing ones. | ||
*Myxoid sarcomas, e.g. [[myxoid chondrosarcoma]]. | |||
===Images=== | ===Images=== | ||
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==IHC== | ==IHC== | ||
*S100 +ve - highlights the fat. | *S100 +ve<ref name=pmid18702357/> - highlights the fat. | ||
==Sign out== | ==Sign out== | ||
===Biopsy=== | |||
<pre> | |||
Right Upper Lobe of Lung, Core Biopsy: | |||
- Chondromyxoid neoplasm, favour pulmonary hamartoma versus chondroma, | |||
see comment. | |||
- Scant lung parenchyma, benign. | |||
Comment: | |||
The lesion stains with S-100. | |||
</pre> | |||
===Excision=== | |||
<pre> | <pre> | ||
LUNG LESION, LEFT UPPER LOBE, WEDGE RESECTION: | LUNG LESION, LEFT UPPER LOBE, WEDGE RESECTION: | ||
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</pre> | </pre> | ||
===Micro=== | ====Micro==== | ||
The sections show lung with a well circumscribed lesion with a fibrous capsule partially lined by respiratory-type epithelium. The lesion consists of abundant respiratory epithelium and glands with focal sheeting and small collections of neutrophils focally. Small foci of degenerative changes are seen. The epithelium of the lesion as a bland cytomorphology. Mitotic activity is not readily apparent. Fat is not identified as a component of the lesion. Around the periphery of the lesion pulmonary edema is present. | The sections show lung with a well circumscribed lesion with a fibrous capsule partially lined by respiratory-type epithelium. The lesion consists of abundant respiratory epithelium and glands with focal sheeting and small collections of neutrophils focally. Small foci of degenerative changes are seen. The epithelium of the lesion as a bland cytomorphology. Mitotic activity is not readily apparent. Fat is not identified as a component of the lesion. Around the periphery of the lesion pulmonary edema is present. | ||
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==See also== | ==See also== | ||
*[[Pulmonary pathology]]. | *[[Pulmonary pathology]]. | ||
*[[Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis]]. | |||
*[[Hamartoma]]. | |||
==References== | ==References== | ||