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Difference between revisions of "Pulmonary carcinoid tumourlet"
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Pulmonary carcinoid tumourlet (view source)
Revision as of 03:30, 22 March 2018
, 03:30, 22 March 2018no edit summary
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Lung carcinoid tumourlet - low mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Lung carcinoid tumourlet. [[H&E stain]]. | ||
| Synonyms = carcinoid tumourlet | | Synonyms = carcinoid tumourlet | ||
| Micro = cells with salt and pepper chromatin, usually nested architecture, no necrosis, minimal mitotic activity (see below) | | Micro = cells with salt and pepper chromatin, usually nested architecture, no necrosis, minimal mitotic activity (see below), must be through the bronchial basement membrane | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[pulmonary neuroendocrine cell hyperplasia]], [[typical carcinoid lung tumour]], [[atypical lung carcinoid tumour]] | | LMDDx = [[pulmonary neuroendocrine cell hyperplasia]], [[typical carcinoid lung tumour]], [[atypical lung carcinoid tumour]], [[pulmonary meningothelial-like nodule]] | ||
| Stains = | | Stains = | ||
| IHC = Ki-67 ~2% (0-7%) | | IHC = Ki-67 ~2% (0-7%) | ||
| Line 17: | Line 17: | ||
| Site = [[lung]] - see ''[[lung tumours]]'' | | Site = [[lung]] - see ''[[lung tumours]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = [[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] | ||
| Clinicalhx = often an incidental finding | | Clinicalhx = often an incidental finding | ||
| Signs = | | Signs = | ||
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*Neuroendocrine cells - usually in nests (classic pattern). | *Neuroendocrine cells - usually in nests (classic pattern). | ||
**Salt and pepper chromatin - '''key feature'''. | **Salt and pepper chromatin - '''key feature'''. | ||
*Nuclei round or ellipsoid. | |||
*Size criterion: <5 mm.<ref name=pct_ucsf>URL: [http://pathhsw5m54.ucsf.edu/case7/image75.html http://pathhsw5m54.ucsf.edu/case7/image75.html]. Accessed on: 23 January 2012.</ref><ref name=pmid23205296>{{Cite journal | last1 = He | first1 = P. | last2 = Gu | first2 = X. | last3 = Wu | first3 = Q. | last4 = Lin | first4 = Y. | last5 = Gu | first5 = Y. | last6 = He | first6 = J. | title = Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis. | journal = J Thorac Dis | volume = 4 | issue = 6 | pages = 655-8 | month = Dec | year = 2012 | doi = 10.3978/j.issn.2072-1439.2012.06.11 | PMID = 23205296 }}</ref> | *Size criterion: <5 mm.<ref name=pct_ucsf>URL: [http://pathhsw5m54.ucsf.edu/case7/image75.html http://pathhsw5m54.ucsf.edu/case7/image75.html]. Accessed on: 23 January 2012.</ref><ref name=pmid23205296>{{Cite journal | last1 = He | first1 = P. | last2 = Gu | first2 = X. | last3 = Wu | first3 = Q. | last4 = Lin | first4 = Y. | last5 = Gu | first5 = Y. | last6 = He | first6 = J. | title = Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis. | journal = J Thorac Dis | volume = 4 | issue = 6 | pages = 655-8 | month = Dec | year = 2012 | doi = 10.3978/j.issn.2072-1439.2012.06.11 | PMID = 23205296 }}</ref> | ||
*Must be through the bronchial basement membrane.<ref name=pmid20729444>{{Cite journal | last1 = Koo | first1 = CW. | last2 = Baliff | first2 = JP. | last3 = Torigian | first3 = DA. | last4 = Litzky | first4 = LA. | last5 = Gefter | first5 = WB. | last6 = Akers | first6 = SR. | title = Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids. | journal = AJR Am J Roentgenol | volume = 195 | issue = 3 | pages = 661-8 | month = Sep | year = 2010 | doi = 10.2214/AJR.09.3811 | PMID = 20729444 }}</ref> | *Must be through the bronchial basement membrane.<ref name=pmid20729444>{{Cite journal | last1 = Koo | first1 = CW. | last2 = Baliff | first2 = JP. | last3 = Torigian | first3 = DA. | last4 = Litzky | first4 = LA. | last5 = Gefter | first5 = WB. | last6 = Akers | first6 = SR. | title = Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids. | journal = AJR Am J Roentgenol | volume = 195 | issue = 3 | pages = 661-8 | month = Sep | year = 2010 | doi = 10.2214/AJR.09.3811 | PMID = 20729444 }}</ref> | ||
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*[[Pulmonary neuroendocrine cell hyperplasia]] - proliferation confined by bronchial basement membrane.<ref name=pmid20729444>{{Cite journal | last1 = Koo | first1 = CW. | last2 = Baliff | first2 = JP. | last3 = Torigian | first3 = DA. | last4 = Litzky | first4 = LA. | last5 = Gefter | first5 = WB. | last6 = Akers | first6 = SR. | title = Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids. | journal = AJR Am J Roentgenol | volume = 195 | issue = 3 | pages = 661-8 | month = Sep | year = 2010 | doi = 10.2214/AJR.09.3811 | PMID = 20729444 }}</ref> | *[[Pulmonary neuroendocrine cell hyperplasia]] - proliferation confined by bronchial basement membrane.<ref name=pmid20729444>{{Cite journal | last1 = Koo | first1 = CW. | last2 = Baliff | first2 = JP. | last3 = Torigian | first3 = DA. | last4 = Litzky | first4 = LA. | last5 = Gefter | first5 = WB. | last6 = Akers | first6 = SR. | title = Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids. | journal = AJR Am J Roentgenol | volume = 195 | issue = 3 | pages = 661-8 | month = Sep | year = 2010 | doi = 10.2214/AJR.09.3811 | PMID = 20729444 }}</ref> | ||
*[[Typical carcinoid lung tumour]] - must be >= 5 mm. | *[[Typical carcinoid lung tumour]] - must be >= 5 mm. | ||
*[[Pulmonary meningothelial-like nodule]] - whorled appearance, ''not'' associated with an airway. | |||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Lung carcinoid tumourlet - very low mag.jpg | CT - very low mag. (WC) | |||
Image: Lung carcinoid tumourlet - low mag.jpg | CT - low mag. (WC) | |||
Image: Lung carcinoid tumourlet - intermed mag.jpg | CT - intermed. mag. (WC) | |||
Image: Lung carcinoid tumourlet - high mag.jpg | CT - high mag. (WC) | |||
Image: Lung carcinoid tumourlet - alt - high mag.jpg | CT - high mag. (WC) | |||
Image: Lung carcinoid tumourlet - very high mag.jpg | CT - very high mag. (WC) | |||
Image: Lung carcinoid tumourlet - alt - very high mag.jpg | CT - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://pathhsw5m54.ucsf.edu/case7/image75.html Tumourlets - several images (ucsf.edu)]. | *[http://pathhsw5m54.ucsf.edu/case7/image75.html Tumourlets - several images (ucsf.edu)]. | ||