Pulmonary blastoma
Pulmonary blastoma is a very rare tumour of the lung.
General
- Very rare ~ 100 cases in the literature.[1]
- Abysmal prognosis - 5-year survival ~ 15%.[1]
- Typical patient <20 years old.[2]
- Adults usu. in 40s.
Subtypes:[3]
- Well-differentiated fetal adenocarcinoma (WDFA).
- Classic biphasic pulmonary blastoma (CBPB).
- Pleuropulmonary blastoma - considered a separate entity.
Gross
- Lung tumour.
Microscopic
Features:
- Epithelial component:
- Mesenchymal component:
- Small round cells.
DDx:
Images
IHC
Features:[4]
- TTF-1 +ve.
- S-100 -ve.
- Vimentin -ve.
- EMA -ve.
See also
References
- ↑ 1.0 1.1 Alahwal, MS.; Maniyar, IH.; Saleem, F.; Alshiekh, M. (2012). "Pulmonary blastoma: a rare primary lung malignancy.". Case Rep Med 2012: 471613. doi:10.1155/2012/471613. PMC 3461274. PMID 23049565. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461274/.
- ↑ Jethava, A.; Dasanu, CA. (Jan 2013). "Adult biphasic pulmonary blastoma.". Conn Med 77 (1): 19-22. PMID 23427368.
- ↑ Van Loo, S.; Boeykens, E.; Stappaerts, I.; Rutsaert, R. (Aug 2011). "Classic biphasic pulmonary blastoma: a case report and review of the literature.". Lung Cancer 73 (2): 127-32. doi:10.1016/j.lungcan.2011.03.018. PMID 21513998.
- ↑ Zhang, GQ.; Fang, XZ.; Wang, BQ.; Sun, W.; Salai, AD. (Apr 2007). "[Clinicopathological and immunohistochemical features of pulmonary blastoma: analysis of 4 cases and review of the literature].". Zhonghua Yi Xue Za Zhi 87 (15): 1040-2. PMID 17672968.