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Difference between revisions of "Prostate gland"
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→HGPIN (high grade prostatic intraepithelial neoplasia): +images
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**Two cell layers (as in normal prostate glands). | **Two cell layers (as in normal prostate glands). | ||
== | ==High grade prostatic intraepithelial neoplasia== | ||
===General=== | ===General=== | ||
*Abbreviated as ''HGPIN''. | |||
*Thought to be a precursor lesion for prostate adenocarcinoma. | *Thought to be a precursor lesion for prostate adenocarcinoma. | ||
Low-grade PIN: | |||
*Not reported and generally believed to be irrelevant biologically/clinically. | |||
**''PIN'' not otherwise specified refers to ''HGPIN''. | |||
**Low-grade PIN has the architecture of HGPIN but lacks the nuclear atypia. | |||
===Microscopy=== | ===Microscopy=== | ||
Features: | |||
*Diagnosed on basis of nuclear changes. | *Diagnosed on basis of nuclear changes. | ||
**Hyperchromatic nuclei. | **Hyperchromatic nuclei. | ||
**Nucleoli present. | **Nucleoli present - '''key feature'''. | ||
**Often increased N/C ratio. | **Often increased N/C ratio. | ||
*Different architectures (e.g. | *Different architectures (e.g. micropapillary). | ||
*Usually epithelial hyperplasia. | *Usually epithelial hyperplasia. | ||
====HGPIN architecture==== | ====HGPIN architecture==== | ||
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Note: The architectural pattern is NOT thought to have any prognostic significance -- may, however, be useful for picking it out from benign prostate. | Note: The architectural pattern is NOT thought to have any prognostic significance -- may, however, be useful for picking it out from benign prostate. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:High-grade_prostatic_intraepithelial_neoplasia_low_mag.jpg HGPIN - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:High-grade_prostatic_intraepithelial_neoplasia_intermed_mag.jpg HGPIN - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:High-grade_prostatic_intraepithelial_neoplasia_high_mag.jpg HGPIN - high mag. (WC)]. | |||
===Differentiating between diagnoses=== | ===Differentiating between diagnoses=== | ||